Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Unit 2 Pharm Drugs > Adrenergic Receptor Agonists > Flashcards

Adrenergic Receptor Agonists Flashcards

1
Q

Physiologic Effect at Alpha 1 Receptors

A
  1. Vasoconstriction (most smooth muscle responds to alpha 1 stimulation by constriction)
  2. Increased peripheral resistance
  3. Increased blood pressure
  4. Affects arterioles in skin, mucosa, viscera, kidneys, veins, uterus, and spleen
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Physiologic Effect at Alpha 2 Receptors

A
  1. Inhibition of NE release and ACh release
  2. Inhibition of insulin release
  3. Affects presynaptic nerve endings and postsynaptic nerves in CNS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Physiologic Effect at Beta 1 Receptors

A
  1. Primarily affects the heart and kidneys
  2. Tachycardia
  3. Increased lipolysis
  4. Increased myocardial contractility
  5. Increased renin release
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Physiologic Effect at Beta 2 Receptors

A
  1. Affects arterioles/arteries, bronchial muscle, pregnant uterus
  2. Vasodilation
  3. Slightly decreased peripheral resistance
  4. Bronchodilation
  5. Increased muscle and liver glycogenolysis
  6. Increased release of glucagon
  7. Relax uterine smooth muscle
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Physiologic Effect at Dopamine 1 Receptors

A
  1. Dilates renal, splanchnic, and cerebral arterioles and increases blood flow to kidneys and other viscera
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Norepinephrine (Levophed) Class

A

Non-selective agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Norepinephrine MOA

A

Agonist: α1, α2, β1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Norepinephrine Effects

A

Alpha 1: vasoconstriction and increased bp

Beta 1: Increased hr, conduction, and contractility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Norepinephrine Indications

A

Restore bp in acute hypotension or during cardiac arrest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Alpha Agonist Uses

A
  1. Control hemorrhage
  2. Contain local anesthetic
  3. Nasal decongestant
  4. Allergic (anaphylactic) shock
  5. Glaucoma
  6. Hypotension
  7. Shock
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Norepinephrine Side Effects

A
  1. Hypertension
  2. Arrhythmias
  3. Headache
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Epinephrine Class

A

Non-selective agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Epinephrine MOA

A

Agonist: α1, (α2), β1, β2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Epinephrine Indications

A
  1. Control hemorrhage
  2. Hypotension
  3. Shock
  4. Allergic reaction
  5. Cardiac Arrest
  6. AV Block
  7. Glaucoma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Epinephrine Effects

A
  1. Alpha 1: vasoconstriction and increased bp
  2. Beta 1: Increased heart rate and contractivilty
  3. Beta 2: vasodilation, decreased diastolic pressure, bronchodilation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Epinephrine Side Effects

A
  1. Palpitations
  2. Arrhythmias
  3. Headache
  4. Tremors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Amphetamine and Dextroamphetamine Class

A

Indirect Acting Agonist, CNS Stimulant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Amphetamine and Dextroamphetamine MOA

A

Increase amount of catecholamines in synaptic cleft by releasing intracellular stores of NE, dopamine, and seratonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Amphetamine and Dextroamphetamine Effects

A
  1. Increased alertness
  2. Decreased fatigue
  3. Decreased appetite
  4. Insomnia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Amphetamine and Dextroamphetamine Side Effects

A

Though to be the result of adrenergic activity

  1. Vertigo
  2. HTN
  3. Confusion
  4. Nausea
  5. Diarrhea
  6. Insomnia
  7. Anxiety
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Amphetamine and Dextroamphetamine Indications

A 
Amphetamine
1. Narcolepsy
2. Recreation
Dextroamphetamine
1. ADHD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Phenylephrine (Neo-synephrine) Class

A

α1-selective α agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Phenylephrine (Neo-synephrine) MOA

A

Agonist: α1

24
Q

Phenylephrine (Neo-synephrine) Indications

A
  1. Nasal and ocular decongestant
  2. Treatment of drug induced hypotension
  3. Diet aids
25
Q

Phenylephrine Side Effects

A
  1. HTN

2. Reflex bradycardia

26
Q

Clonidine (Catapres) Class

A

α2-selective α agonist

27
Q

Clonidine (Catapres) MOA

A

Agonist: CNS α2, decreases sympathetic outflow from vasomotor center

28
Q

Clonidine (Catapres) Indications

A
  1. HTN
  2. Prevents withdrawal syndrome from opioids and alcohol
  3. Shock
29
Q

Clonidine (Catapres) Side Effects

A
  1. Sedation

2. Retention of salt and water

30
Q

α-methyldopa (Aldomet) Class

A

α2-selective α agonist

31
Q

α-methyldopa (Aldomet) MOA

A

Metabolite (a-methylnorepinephrine) activates CNS a2 receptors

32
Q

α-methyldopa (Aldomet) Indications

A
  1. Hypertension
33
Q

α-methyldopa (Aldomet) Side Effects

34
Q

Isoproteranol (Isuprel) Class

A

Non-selective β agonist

35
Q

Isoproteranol (Isuprel) MOA

A

Agonist: β1, β2
Beta 1: Increased heart rate, conduction, and contractility
Beta 2: vasodilation and dec diastolic BP, bronchodilation

36
Q

Isoproteranol (Isuprel) Indications

A
  1. Cardiac Arrest
  2. AV Block
  3. Shock
37
Q

Isoproteranol (Isuprel) Side Effects

A
  1. Palpitations
  2. Arrhythmias
  3. Headache
  4. Tremor
38
Q

Dobutamine (Dobutrex) Class

A

β1-selective β agonist

39
Q

Dobutamine (Dobutrex) MOA

A

Agonist: β1

Increases cardiac contractility, cardiac output, and heart rate

40
Q

Dobutamine (Dobutrex) Indications

A
  1. Cardiogenic shock
  2. Acute CHF
  3. Heart Block
41
Q

Albuterol (Proventil, Ventolin) Class

A

β2-selective β agonist

42
Q

Albuterol (Proventil, Ventolin) MOA

A

Agonist: β2

Relaxes bronchial, uterine, and vascular smooth muscle

43
Q

Albuterol (Proventil, Ventolin) Indications

A
  1. Prevent or treat bronchospasm
  2. Mild exercise-induced asthma
  3. COPD
44
Q

Albuterol (Proventil, Ventolin) Side Effects

A
  1. Tachycardia
  2. Tremors
  3. May mask progressively more severe inflammation
45
Q

Terbutaline (Breathine) MOA

A

Adrenergic receptor agonist

46
Q

Terbutaline (Breathine) Therapeutics

A

Prevent or reverse exercise induced bronchospasm, mild asthma, COPD, early labor

47
Q

Terbutaline (Breathine) SE

A
  1. Can mask progressively severe inflammation

2. Tachycardia, muscle tremor

48
Q

Terbutaline (Breathine) Misc

A

10-15 minutes to take action, 6-12 hours (max) of duration; nebulizer delivers more, but greater side effects; oral is least effective (requires more dose –> side effects); can be used night symptoms, but not ideal

49
Q

Fenoldopam (Corlopam) MOA

A

Agonist, D1 receptor only

50
Q

Fenoldopam (Carlopam) Therapeutics

A

Increase blood flow at renal, mesenteric, and cerebral arteries

51
Q

Fenoldopam (Carlopam) Misc

A

~ 10 minute half life

52
Q

Dopamine MOA

A

Agonist at D1, alpha 1, and Beta 1 receptors

53
Q

Dopamine Therapeutics

A

Shock, renal failure, hypotension

54
Q

Dopamine SE

A

Vasoconstriction at high doses

55
Q

Dopamine Misc

A

Low dose = Direct @ D1 Receptors
Medium dose = Direct @ Beta 1, some Indirect
High dose = Direct @ Alpha 1, some Indirect

Unit 2 Pharm Drugs (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions