Adrenergic drugs Flashcards
What varies based on site of action and effects on receptor type
Therapeutic uses for adrenergic compounds
What are the 2 names of adernergic drugs which stimulate the SNS
adernergic agonist or sympathomimetics
What are the SNS neurotransmitters (catecholamines)
norepinephrine and epinephrine from the adrenal medulla and dopamine
What two systems make up the ANS and provide checks and balance
SNS (fight/flight) and PNS (relax/digest)
What are adrenergic receptor sites
places where drugs bind to produce effect they are located throughout the body for NE and Epinephrine catecholamines
What are the 2 categories of adrenergic receptors
alpha and beta
Alpha 1 receptors are located where
postsynaptic effector cells the nerve stimulates (one after)
Alpha 2 receptors are located where
presynaptic nerve terminals release neurotransmitters (2 before)
What is the dominant alpha adrenergic response
vasoconstriction and CNS stimulation. Alpha-constrictor
Tony of P90X says eat apples 2 before and 1 after a workout. Say What?
Alpha 2 are presynaptic, Alpha 1 are postsynaptic
All beta adrenergic receptors are located
postsynaptic effector cells
Beta 1 are located where
Heart (1love) and kidney
Beta 2 are located on smooth muscles fibers of
bronchioles, arterioles and visceral organs like uterus (oxytocin)
Beta adrenergic drugs AGONIST relaxes my
lungs, stomach and womb but it stimulates my heart and cause glycogenolysis
Alpha 2 and Beta 1 has the same effect in the
liver (glycogenolysis) and stomach (decrease motility)
Beta 1 in the kidney does…
increase renin, volume and ultimately blood pressure
Alpha 1 causes what in the eye
mydriasis
The dopamine adernergic receptors causes dilation to
renal, mesenteric, coronary and cerebral arteries to and thereby increase blood flow to the tissues. Dope dilates at MCRC.
The 2 enzymes responsible for stopping the catecholamine actions are MAO and COMT
MAO (pre) and COMT (synapse)
What are the B1 effects the pancreas
decrease insulin release/increase glucose
What receptors does the synthetic catecholamines stimulate
dobutamine (B1)
phenylephrine (A1)
epinephrine stimulates what mostly
B1
norepinephrine stimulates
A1
Amphetamines are an example of indirect acting sympathomemetics which means it causes a
release of neurotransmitters from storage sites