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Pharm Exam 3 > Adrenergic Agonists and Blockers (3) > Flashcards

Adrenergic Agonists and Blockers (3) Flashcards

1
Q

Alpha 1

A

INCREASE BP
VASODIALATION
increases cardiac contractility
dilates pupils
urinary bladder relaxation
contraction of prostate
ejaculation
dry mouth
blurred vision

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2
Q

Effects of Adrenergic Agonists

A

Triggers fight or flight (sympathetic nervous system)

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3
Q

Beta 1

A

INCREASES HR
increases cardiac contractility
increases renin secretion
increases bp

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4
Q

Beta 2

A

BRONCHODIALATION
decreases GI tone and motility
increases blood flow in skeletal muscles
activates liver glycogenolysis
increases bloodsugar

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5
Q

Vasodilation

A

increases blood flow to the vital organs

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6
Q

Dopaminergic

A

located renal, mesenteric (around internal organs), coronary, and cerebral arteries

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7
Q

Epinephrine Side Effects

A

cardiac dysrhythmias
tachycardia
dizziness
headache
sweating
insomnia
tremors
hyperglycemia

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8
Q

Epinephrine drug interactions

A

beta-blockers (decrease epi action)
digoxin (cardiac dysrhythmias)
TCAs and MAOIs (intensify and prolong effects)

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9
Q

Epinephrine Action

A

Adrenaline
Nonselective
Alpha1 increases the bp
beta1 increases hr
beta2 promotes bronchodilation
inotropic beta1 effects
vasoconstrictor
bronchodilator

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10
Q

Epinephrine contraindications

A

cardiac dysrhythmias
hypertension
hyperthyroidism
diabetes
pregnancy

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11
Q

Epinephrine uses

A

anaphylaxis
bronchospasms
cardiogenic shock
cardiac arrest

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12
Q

Catecholamines

A

produce sympathetic response
endogenous (epi, norepi, dopamine)
synthetic (isoproterenol)

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13
Q

noncatecholamines

A

Stimulate adrenergic receptors
longer duration than endogenous and synthetic (phenylephrine, albuterol)

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14
Q

Direct acting

A

Directly stimulates the adrenergic receptor
(Epi, Norepi)

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15
Q

indirect-acting

A

stimulates the release of norepinephrine from terminal nerve endings
(amphetamine)

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16
Q

mixed- acting

A

stimulates adrenergic receptor sites and stimulates the release of norepinephrine from terminal nerve endings
(ephedrine)

17
Q

neurotransmitter inactivation

A

reuptake of transmitter back into neuron
enzymatic transformation or degradation
diffusion away from the receptor

18
Q

Drugs that halt the termination of neurotransmitters by inhibiting

A

norepi reuptake
norepi degradation

19
Q

Sympathetic Nervous System

A

Adrenergic
(Fight or flight)

20
Q

Adrenergic Response

A

dilate pupil
increase hr
bronchodilate
vasoconstriction
gi relaxation
bladder relaxation
uterus relaxation

21
Q

Albuterol (Proventil) action

A

selective
acts on beta2 adrenergic receptors
promotes bronchodialtion
PO, Inhaler, Nebulized

22
Q

Albuterol uses

A

treat bronchospasms
asthma
bronchitis
COPD

23
Q

Albuterol caution

A

severe cardiac disease
hypertension
hyperthyroidism
diabetes
pregnancy
renal dysfunction

24
Q

Albuterol side effects

A

tremors
dizziness
palpitations
tachycardia
cardiac dysrhythmias
restlessness
nervousness

25
Q

Albuterol drug interations

A

increase effects of sympathomimetics, MAO inhibitors, and tricyclic antidepressants
antagonize effects of beta blockers

26
Q

Adrenergic Blockers/ antagonists

A

sympatholytics
blocks the effects of adrenergic neurotransmitter
block alpha and beta receptors

27
Q

types of adrenergic blockers

A

alpha-adrenergic antagonists
1. selective
2. non-selective
beta-adrenergic antagonists
1. selective
2. non-selective

28
Q

effects of adrenergic blockers
(alpha 1)

A

vasodilation
ortho hypotension
pupil constriction
suppresses ejaculateation
reduces the contraction of smooth muscles
reduces contraction of bladder

29
Q

effects of adrenergic blockers
(beta 1)

A

reduces cardiac contractility
decreases pulse

30
Q

effects of adrenergic blockers
(beta 2)

A

bronchoconstriction
contracts uterus
inhibits glycogenolysis

31
Q

alpha blockers

A

drugs that inhibit response at alpha-adrenergic receptor
selective (block alpha 1)
non-selective (block alpha 1 and 2)
promotes vasodilation
decreases symptoms of hypertrophy and vascular disease

32
Q

beta-blockers

A

decrease bp and pulse
nonselective (beta 1 and 2)
usually ends in lol
used for angina, hypertension, heart failure
selective (beta 1 only)

33
Q

side effects of beta blockers

A

bradycardia
hypotension
headaches
drowsiness
dizziness
gi distress
fainting
depression

34
Q

Adrenergic neuron blockers

A

inhibit release of norepi at synapse
decrease bp
resperine (can cause vivid dreams)
adrenergic neuron blockers
sodium and water retention
peripherally acting sympatholytics

Pharm Exam 3 (5 decks)

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