Adrenergic Agonist Eliud Flashcards
What is the most common treatment of adrenergic drugs?
-Asthma
-Hypertension
-Common Cold Symptoms
Which neurotransmitter is at the terminus of the sympathetic nervous system?
Norepinephrine
Which neurotransmitter is synthesized mainly in the adrenal gland?
Epinephrine
Describe the Biosynthesis of Norepinephrine
- L-Tyrosine enters the presynaptic neurons via active transport and oxidize it though Tyrosine Hydroxylase to form L-DOPA (rate-limiting step).
- L-Dopa decarboxilation by Dopa decarboxylase to produce Dopamine which are stored in vesicles.
- Dopamine is oxidized by Dopamine-B-Hydroxylase to form Norepinephrine.
Storage and Release of Norepinephrine
-95% is reuptake through a transporter.
-Alpha 2 inhibits NE release
-NE can be metabolized through MAO or COMT
True or False: El metabolismo de Norepinefrina crea un metabolito inactivo bien hidrofilico para excretar.
True
Alpha 1 Receptors
Predominantly postsynaptic found in vascular smooth muscle and the CNS
Alpha 2 Receptors
Stimulation inhibits NE release
Beta 1 Receptors
Found in myocardial. Stimulation increase heart rate and force of contraction.
Beta 2 Receptors
Found in lungs, vascular smooth muscle, skeletal muscle, and uterus. Stimulation results in dilation or relaxation of these tissues.
Adrenergic Receptors: Asp 113
La más importante ya que está con carga negativa lo que ayuda a atraer el nitrógeno positivo de NE creando un enlace ionico.
Adrenergic Receptors: Ser204 and Ser207
Reconoce a los OH de anillo aromático
Adrenergic receptors: Phe290
Interactúa con el grupo fenol por van der waals
Adrenergic Receptors: Asn293
Puentes de hidrógeno con el OH del carbono B que tiene que está en conformación R para ser reconocido.
What is the base structure of Phenylethylamine Adrenergic Agonist?
Benzenediol structure. NH2 al final luego de dos carbonos entremedio.