Adrenegic Indirect Agonist

Question 1

Indirect agonist target

Answer 1

-Inhibition of Tyrosine Hydroxylase
-Blocking of Norepinephrine uptake into vesicles (reserpine)
-Blocking of Norepinephrine release from vesicles (guanetgidine)
-Postjunctional receptors can be activated or blocked
-Inhibition of COMT and MAO
-Re-uptake inhibition (cocaine)
-Displacement of Norepinephrine from the mobile pool (False transmitter)
-Pre-junctional alpha receptors cause inhibition of norepinephrine release (Clonidine and alpha Methyldopa)

Question 2

Which two pool catecholamines originates?

Answer 2

De Novo synthesis and recycled transmitter.

The effects they may have are short-term (increase release) or long-term (depletes the pool of catecholamines).

Question 3

Cuál es el falso transmisor por excelencia?

Answer 3

Guanetinina

Question 4

Problem of false neurotransmitters?

Answer 4

Initially they release NE but in the long run not many NE will be left to be released

Question 5

Guanethidine

Answer 5

Ya no se usa. Used for hypertension. Accumulates in the vesicle to release NE.

Question 6

Reserpine

Answer 6

Irreversibly damages VMATs which makes vesicles lose their ability to concentrate and store NE and DA

Used to treat hypertension

Question 7

True or False: Direct acting sympathomimetic responses are not reduced by prior treatment with reserpine and guanethidine

Answer 7

True

Indirect acting sympathomimetic responses are abolished by prior treatment with reserpine and guanethidine

Question 8

What catecholamine release agent can be found in fermented foods?

Answer 8

Tyramine

-Is a false neurotransmitter that can cause hypertension (pentolamina trata crisis hipertensiva)

Question 9

Amphetamine

Answer 9

False neurotransmitter

-to treat ADHD and narcolepsy
-there is also Dextroamphetamine (less peripheral action) and modafinil (few psychoactive effect)

Question 10

Cocaine

Answer 10

Acts by inhibiting the reuptake of neurotransmitters