Adrenal

Question 1

addison’s disease

Answer 1

most common primary adrenal insufficiency

-ACTH stimulation test: cortisol low at all intervals

Question 2

adrenal crisis

Answer 2

previously undiagnosed adrenal insufficiency
labs wildly off
set off by stress/infx

Question 3

congenital adrenal hyperplasia

Answer 3

deficient cortisol synth
compensatory ACTH inc
overproduction of blocked steroid precursors

Question 4

21-hydroxylase deficiency

Answer 4

most common congenital adrenal hyperplasia

-inc adrogens, dec mineralocorticoids

Question 5

21-hydroxylase deficiency treatment

Answer 5

dexamethasone

Question 6

primary hyperaldosteronism

Answer 6

hyporeninenemic hyperaldosteronism
adrenal adenoma/conn’s syndrome: surgical
BL adrenal hypertropy: spironolactone (ald antag)

Question 7

secondary hyperaldosteronism

Answer 7

hyperreninemic hyperaldosteronism

-Tx: aldosterone antag (spironolactone)

Question 8

pheochromocytoma

Answer 8

overprod of metanephrine/normetanephrine
diaphoretic
clonidine suppression test

pre-op phenoxybenzamine