ADME Distribution Flashcards
1
Q
What does distribution mean?
A
Transfer of the drugs from the bloodstream to tissues around the body
2
Q
what type of drugs may be able to bypass tissue barriers?
A
Highly lipid soluble drugs
lipophilic drugs are more likely to get into the CNS
3
Q
What type of drugs usually bind to plasma proteins?
A
drugs that are less water soluble.
4
Q
plasma proteins binding is a ______ process
A
saturable, reversible process, influenced by concentration, when the drug is bound it is inactive.
5
Q
certain proteins bind to certain drugs acidic drugs typically bind to?
A
albumin
6
Q
if two highly protien bound drugs are given at the same time then…
A
drug displacement by occur, leading to an increased amount of active “free” drug in circulation and possible toxicity.
