ADME Absorption Flashcards
What is absorption?
Movement of the drug from the site of administration into the blood.
What is Dissolution?
Drug molecules enter the solution
What is Disintegration?
physical dispersion of a solid dosage form
What is Bio-availability?
the fraction of a given does that ends up in systemic circulation
IV administration has no _____ phase?
no absorption phase, it is considered to represent 100% bioavailability
systemic means?
that a drug is intended to reach the blood stream
Enteral means?
drug administered via the Gastrointestinal Tract
Where does most of the absorption take place of an Enteral administered medications?
the small intestine, large surface area, rich blood supply, and microorganisms
weak acids tend to be nonionized in _____ environments
in acid environments, and may be better absorbed in the stomach
weak bases are poorly absorbed in the ____
stomach (ionized) and often better absorbed in the Small intestine
What is enterohepatic recycling
a special situation in which a drug is absorbed into portal circulation, metabolized and excreted in the bile then reabsorbed for the SI.
may have longer half life
what is first pass metabolism?
a special situation in which an oral drug is absorbed into portal circulation and a portion of the drug is metabolized before it reaches circulation.
associated with lower bioavailability
What is pre-systemic metabolism?
any metabolism which occurs before the drugs goes into systemic circulation.
what does Parenteral mean?
any route other than Enternal (PO)
How is transdermal absorption manipulated?
increase lipophilicity, increase local humidity, or provide a very high local concentration
