Adipose Tissue

Question 0

What is Leptin and where is it produced? Is used for long or short term weight regulation?

Answer 0

Leptin is a hormone created in white adipose tissue that helps regulate appetite and body energy expenditures. It signals to the brain about body fat stores. Long-term regulation.

More fat tissue–> more leptin–> lower appetite, burn fat stores
Less fat tissue–>less leptin–>increase appetite, store fat.

Question 1

What are the functional differences between white and brown adipose tissue?

Answer 1

White adipose tissue serves as energy storage, insulation, cushioning, hormone production, and the source of metabolic water.

Brown adipose tissue aids in heat production, also known as thermogenesis.

Question 2

What are the long-term weight regulation hormones?

Answer 2

Leptin and insulin.

Question 3

What are the short-term weight regulation hormones?

Answer 3

Grehlin and Peptide YY

Question 4

What is the master switch for a white adipose tissue development?

Answer 4

PPAR/RXR transcription factors

Question 5

What is the master switch for brown adipose tissue development?

Answer 5

PRDM16/PGC-1

Question 6

Name 5 insulin adipose produced molecules that may be linked to obesity?

Answer 6

Tumor necrosis factor
Transforming growth factor
Insulin like growth factor I
Interleukin 6
Prostaglandins

Question 7

What hormones and neural pathways affect regulation of adipose tissue?

Answer 7

Leptin
Insulin
Thyroid hormones
Adrenal steroids
Glucagon
Growth factor hormone (pituitary) 
Norepinephrine initiates lipase (breakdown fat)