ADHD Flashcards
What is the clinical phenotype of ADHD?
Inattention, hyperactivity, and impulsivity
What are ADHD types?
Predominantly inattentive
Predominantly hyperactive/impulsive
Combined
What are diagnostic criteria?
For children: 6 or more symptoms in one domain
For adolescents/adults >17: 5 or more symptoms
Impairment in academic/social/occupational functioning
What is boys to girls ratio?
2:1
Girls more likely to have ADHD-I
Does incidence vary as a function of age?
Yes,incidence rate in 10-17 y.o is almost twice as high compared to 5-9 y.o.
Which subtype has the highest prevalence rate?
ADHD-I
What cognitive construct is ADHD-I associated with?
Sluggish cognitive tempo
Which subtype has questionable validity?
ADHD-H
Which brain structures/pathways have been associated with ADHD?
Frontal regions
Reduced total brain volume, delayed cortical maturation in frontal/temporal regions, abnormalities in CC, prefrontal, temporal, and parietal cortex, and BG (most consistent)
What are functional imaging findings in ADHD?
Underactivation in frontocortical nad frontosubcortical networks
Decreased activation in dosrolateral prefrontal and dorsal anterior cingulate cortex
Deficits in network including frontal cortex and striatal-thalamic-cerebellar connections
What is heritability of ADHD?
30-35% first degree relatives
Relative risk 6-8 times that of general population
Genetic influences account for up to 75% of variance
What are candidate genes?
Multiple genes, cumulative effect accounts for a small %
Dopamine transporter DAT1
Genes affective dopamine and serotonin pathways
What are risk factors of ADHD?
Prematurity Birth complications Maternal smoking Lead exposure/toxicity Moderate to severe TBI
ADHD Comorbidities
ADHD w/o comorbid disorder is exception rather than rule
OCD, Tourette, dyslexia, ODD, CD, depression, anxiety
ADHD symptoms common in thyroid dysfunction, bipolar disorder, ADS, Klinefelter syndrome, neurofibromatosis, epilepsy, sleep disorder, and lead toxicity
Inattentive symptoms - internalizing disorders (depression)
H/I - externalizing (ODD, CD)
What are some shared etiological influences?
Chromosome 6p
Processing speed deficits - overlap between ADHD and dyslexia