ADHD Flashcards

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1
Q

what is the DSM5 definition of ADHD? the subtypes?

A

attention deficit hyperactivity disorder now called neurodevelopmental disorder

  • ADHD combined = whole spectrum (OCD and can’t focus; most kids and adults)
  • ADHD inattentive (not hyperactive)
  • ADHD hyperactive/impulsive (focused)
  • other specified or unspecified

must start before age 12, and symptoms in multiple settings, causing social disability

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2
Q

what is “ADD”?

A

attention deficit disorder = ADHD inattentive

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3
Q

what are the requirements for “inattention symptoms”?

A

6 symptoms for 6 mo:

  • poor attention to detail –> mistakes
  • cannot sustain attention
  • doesn’t listen
  • doesn’t follow through
  • doesn’t organize
  • avoids tasks
  • loses things
  • is distracted
  • is forgetful
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4
Q

what are the requirements for “hyperactive/impulsive” symptoms?

A

6 symptoms for 6 mo:

  • fidgets
  • leaves seat
  • runs/climbs
  • not quiet
  • talks a lot
  • blurts out
  • cannot wait turn
  • interrupts
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5
Q

what is the course of ADHD?

A

most often apparent at young age where age-appropriate norms for paying attention and delayed gratification are not met

  • mmilder and more attentive cases may not be noticed until later in life when demands are greater
  • inattentiveness tends to persist greater than hyperactivity/impulsivity
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6
Q

what are the 5 possible etiology for ADHD?

A
  1. genetics and heredity
  2. neuronal/brain developmental delay
  3. neurological/neurotransmitter abnormalities
  4. environmental factors
  5. psychological factors
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7
Q

explain the genetics of ADHD?

A

at least 76% heritable; Xm 16 is the most obvious finding

-genes linked to dopamine, NE, serotonin, neurotransmission, and neuronal plasticity

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8
Q

what does hypo or hyperactivity in terms of neuronal firing and tone cause?

A

major hypo: major depressive disorder, schizophrenia, negative symptoms
mild hypo: ADHD
mild hyper: hypervigilant
major hyper: psychosis

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9
Q

explain the neuronal/brain developmental delay with ADHD?

A

develop 2 years slower in development and pruning
-anterior cingulate (ACC) doesn’t fire, while other areas are active when they shouldn’t be (prefrontal cortex, basal ganglia, cerebellum, temporal/parietal cortex)

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10
Q

what are the key neurotransmitters involved in ADHD?

A

NE - decreased tonic NE firing in PFC
DA - decreased tonic DA firing in PFC
5HT - unknown, but controls locomotion and behavioral and cognitive impulsivity

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11
Q

what are environmental factors for ADHD?

A
  • cigarette/alcohol use in pregnancy
  • lead poisoning
  • head injuries
  • possible high sugar, food color additives?
  • learned behavior or reaction to stress?
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12
Q

what are differential diagnosis and associated conditions with ADHD?

A
  • autism spectrum disorder
  • learning disability
  • substance use disorder
  • personality disorder
  • bipolar disorder
  • anxiety disorder (highest correlation)
  • depression
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13
Q

medication management for ADHD? information on them?

A
  1. stimulant class has great efficacy in adults, teens, children
    - promote DA and NE to increase activity
    - most carry risk of addiction, paranoia in misuse
    - stunted growth (1/4 to 1/2 inch), weight loss (curbed appetite)
    - cardiac issues
  2. non-stimulants have less efficacy but no addiction risk
    - all are sedating, and some (except NRI) may lower BP
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14
Q

what are examples of non-stimulant medications?

A

atomoxetine (NRI; NE reuptake inhibitor) and guanfacine/clonidine ER (extended release; a2 NE agonists)

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15
Q

what is psychotherapy management for ADHD?

A

behavioral modification and training

  • self-control therapy
  • behavioral parent training
  • relaxation
  • education support
  • distraction control
  • attention sustaining
  • cognitive restructuring
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16
Q

what are the “steps” for ADHD pharmacy for pre-schoolers?

A
  1. behavioral therapy
  2. amphetamines
  3. methylphenidate (MPH)
17
Q

what are the “steps” for ADHD pharmacy for children and adolescents?

A
  1. slow-release methylphenidate (MPH)
  2. slow-release amphetamines
  3. immediate release stimulants
  4. clonidine ER, guanfacine ER, atomoxetine (non-stimulants)
18
Q

what are the “steps” for ADHD pharmacy for adults?

A
  1. clonidine ER, guanfacine ER, atomoxetine (non-stimulants)
  2. slow-release amphetamines
  3. slow-release MPH (methylphenidate)
  4. immediate-release stimulants
19
Q

how do non-stimulants work for ADHD?

A

HCN channel linked to cAMP has both a2 (NE) and D1; neurosignals go through here

  • NE –> closed HCN –> less leakage of signal –> more signal and focus (achieved by NRI; NE reuptake inhibitors)
  • -improve signal to noise ratio, allowing neuron to fire appropriately
  • DA –> open HCN –> more leakage –> less focus (preferably inhibit this)
20
Q

what is the prognosis for ADHD?

A

range from poor to excellent

  • sometimes ADHD symptoms promote success and wellbeing, but patients have less school, less powerful jobs, lower self-esteem, more antisocial behavior, greater addiction rates, greater divorce rates, but equal rates of medical illness
  • 2/3 showed no psychopathology or mental disorder in adulthood
21
Q

what are the different non-stimulants and how do they differ?

A
  • atomoxetine: NET inhibitor only (NE reuptake inhibitor)

- guanfacine ER and clonidine ER: agonize or stimulate a2 NE receptor