Adenovirus

Question 1

adenovirus infects where and spreads to where

Answer 1

All areas of resp. tract:

upper resp tract (via resp droplets) and spreads to intestines
- hardly ever causes symptoms

Can also be transmitted via F-O route

Question 2

ad serotypes: 1-5, 7, 21 causes what?

Answer 2

disseminated infxns

- esp in organ transplant patients

Question 3

Pink eye / Conjunctivitis

Answer 3

adenovirus (Group D)

Question 4

Can adenovirus cause obesity?

Answer 4

Yes, ad serotype 36

Question 5

Promising treatment for adenovirus

Answer 5

cydofovir + ribavirin

Question 6

military recruits infected with adeno have what serotype?

Presentation?

Answer 6

Group B: ad serotype
3,7,11,14
also
Group E: 4!

causes acute resp illness, pneumonia

Question 7

considerations for gene therapy

Answer 7

1. Target tissue and disease
2. Ex vivo vs in vivo
3. Sustained or transient expression
4. Vectors

Question 8

SCID

how to use gene therapy?

Answer 8

X linked (defect in IL-2gamma chain) or autosomal recessive (deficiency in adenosine deaminase)
--> sucept to infxn

1. harvest bone marrow
2. repeatedly transduce marrow with retroviral vector
3. reintroduce into pts

Question 9

What serotypes of adenovirus cause diarrhea

Answer 9

40+41

Question 10

Are adenoviruses associated with tumors?

Answer 10

NOPE

Question 11

Most common symptom of adenovirus

Answer 11

asymptomatic

Question 12

Most common resp infxn in kids

Answer 12

1. RSV
2. Parainfluenza
3. Adenovirus

*adeno induced pneumonia is more severe is more freq assoc with fatalities

Question 13

Vaccination for adenovirus

Answer 13

live vaccine 4 mil recruits

• contains serotypes 3, 4, 7, 21
• uses wild type, unattenuated 4 and 7