Additional Flashcards
1
Q
how does 3tc resistance occur
A
methionine turns into valine at RT184
2
Q
what does 3tc(lamuvidine) resistance drugs occur to?
A
Emtricitidine
abacavir
lamiduvine
(They arent exaclt resistamt, but more so complement eachothers mechanisms, when 3tc gets resistace)
3
Q
what is abacavir alleles?
A
HLA-B5701 - indian Americans
4
Q
what is carbamazepine alleles?
A
HLA-A3101 jap/caucasian
HLA-B1502 Chinese
5
Q
what enzyme is used in opioid metabolism?
A
CYP2D6
6
Q
what enzyme is used in warfarin metabolism?
A
CYP2C9
VKORC1
7
Q
what is maraviroc?
A
anti-CCR5
8
Q
what is brentixumab
A
binds to CD30
for NHL
