Addison's Disease Flashcards
what are some causes of Addison’s disease
most common is autoimmune
TB
metastatic carcinoma
what is Addison’s disease
primary adrenal insufficiency
may be deficient in both aldosterone and cortisol
how can Addison’s disease present
aldosterone related:
hypotension (decreased K + Na)
metabolic acidosis
dizziness, postural hypotension, fatigue, craving salt foods
cortisol related:
hypoglycaemia: weakness, confusion, fatigue
hyperpigmentation
anorexia
diagnosis of Addison’s disease
ACTH stimulation test
would not see increased aldosterone and cortisol
what is secondary and tertiary adrenal insufficiency
secondary: decreased ACTH due to pituitary damage
tertiary: long term steriod use, suppression of CRH release from hypothalamus
what is the management of Addison’s disease
hydrocortisone - replaces cortisol
flurocortisol - replaces aldosterone
presentation of an adrenal crisis
severe hypotension (can cause shock)
arrythmia
confusion
N+V
dehydration
abdominal and back pain
management of an adrenal crisis
IV glucocorticoids (as symptoms related to insufficient cortisol)
IV fluids and dextrose
close monitoring
identify and manage underlying cause
