addiction

Question 1

methadone

Answer 1

mu agonist, decrease cravings
MAT to reduce withdrawal S r/t opioids, help stay clean
SE: lightheaded, hives, chest pain, tachy, hallucination, confusion (similar to withdrawal S)
can develop addiction, dependence - daily dose from clinic

Question 2

buprenorphine and naloxone

Answer 2

sublingual and buccal - work fast
SE: HA, opioid withdrawal S, anx, insomnia, sweat, depression, c, n
combine agonist + antagonist - help pt recover faster
abuse potential but less than alone
B: partial opioid agonist, help block receptors to prevent craving, more commonly used now than methadone, can be stand alone
N: opioid antagonist (antidote), block opioid receptors