adaptive and B cells Flashcards
what cell facilitates antibody mediated adaptive immunity
B cells
what characerizes adaptive immunity
memory and specificity
what cell facilitates cell-mediated adaptive immunity
T cells
Where are pro-B cells formed
What is their stem cell name
Where do B cells mature
bone marrow
lymphoblasts
bone marrow
What are recognized by lymphocyte antigen receptors
antigenic determinants
when B cells proliferate, what can they become
plasma cells (making antibodies)
memory cells (for next exposure)
Name the 5 immunoglobulin classes (Ig)
A, E, D, M, G
What is the function of the constant region of Ig’s
combine with other immune cells or part of complement protein system
what is the function of the variable region of Ig’s
specific for antigens with antigen binding sites
Ig’s ___ antigens by altering the antigen’s physical structure.
neutralize
Ig’s binding multiple antigens together
agglutination
Ig’s activating the ___ protein system (inflammation, chemotaxis, and cytolysis)
complement
Ig’s directly activate mast cells and basophils to secrete ___.
histamine
Ig’s stimulate ___ phagocytosis
macrophage
what characterizes primary response (first time exposure response)
B cell proliferation to plasma and memory B cells
Emphasis on neutralizing antigen
Primary response takes longer (lag)
