Acute visual disturbance 2 - optic neuropathies Flashcards

1
Q

optic neuropathy is

A

abnormality or damage to the optic nerves from any cause

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2
Q

symptoms of optic neuropathy

A

visual blurring or loss
or a change in colour vision

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3
Q

disc swelling looks like

A
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4
Q

is optic neuropathy common

A

no its not common but its not rare either

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5
Q

optic disc elevation may be

A

psuedopapilloedema or optic nerve head swelling

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6
Q

optic nerve head swelling may be categorised into

A

elevated ICP and Normal ICP

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7
Q

elevated ICP causes

A

papilloedema
which is bilateral optic nerve head swelling from elevated intracranial pressure

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8
Q

ONH swelling with normal ICP - is this unilateral or bilateral?

A

more commonly unilateral

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9
Q

is elevated ICP usually unilateral or bilateral

A

bilateral

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10
Q

Hx of optic nerve head swelling

A

variable visual change
pain (retro- or periocular)
systemic (paraesthesia, weakness etc)
headache, TVOs, diplopia -> raised ICP

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11
Q

age Hx

A

young - optic neuritis (+/- demyelination)
middle aged - non arteritic ischaemic optic neuropathy NAION (tends to happen in vasculopaths)
elderly - GCA

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12
Q

acute onset minutes/hours

A

NAION, GCA, trauma

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13
Q

subacute onset hours/days

A

optic neuritis

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14
Q

gradual onset (months/years)

A

toxic/nutritional/compressive

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15
Q

examination of papillodaema

A

loss of clarity of the margin of the optic nerve

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16
Q

drusen looks like

A

speckles
looks similar to hard exudate
age related

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17
Q

aetiology of GCA

A

systemic vasculitis of medium/large arteries
causes ischaemia of the optic nerve head

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18
Q

presentation of GCA

A

> 60 years
temporal pain, jaw claudication, discomfort when chewing food, TVOs/diplopia
fatigue, weight loss, myalgia
chalky white disc swelling, cotton wool spots (infarcts of the retina), may also see central artery occlusion
‘cord like’ tender temporal artery with reduced pulse - palpate this as part of the examination

19
Q

management of GCA

A

FBC, ESR, CRP
high-dose steroids
time critical condition, they will lose vision is not treated
temporal artery biopsy to confirm diagnosis

20
Q

prognosis of giant cell arteritis

A

if untreated, one third patients will develop contralateral vision loss over days
may involve the aorta, causing aneurysm, dissection or rupture
threat to sight and life

21
Q

aetiology of papilloedema

A

bilateral optic disc swelling secondary to raised ICP

22
Q

prsentation of papilloedema

A

headache (postural), vomiting, visual disturbance, pulsatile tinnitus

23
Q

DDx of papilloedema

A

tumour, malignant HTN, venous sinus thrombosis, meningitis, idiopathic intracranial hypertension

24
Q

management of papilloedema

A

BP, full neurological exam
MRI/CT head
LP (when SOL excluded)

25
Q

idiopathic intracranial hypertension is a cause of

A

a cause of papilloedema

26
Q

aetiology og idiopathic intracranial hypertension

A

elevated ICP without identifiable cause
usually female of child bearing age, high BMI, may or may not be on the OCP

27
Q

management of idiopathic intracranial hypertension

A

MRI/MRV (exclude SOL/venous sinus thrombosis), then LP
medical: weight loss, salt restriction, acetazolamide, topiramate
surgical: nerve fenestration, neurosurgery (stent), bariatric

28
Q

prognosis of idiopathic intracranial hypertension

A

variable depending on management of ICP, BMI

29
Q

sectoral optic nerve oedema

A
30
Q

non-arteritic ischeamic optic neuropathy aetiology

A

crowded optic nerve head configuration and small vessel arteriosclerosis

31
Q

presentation of non-arteritic ischameic optic neuropathy

A

> 50 years
vascular risk factors, sleep apnoea, symptoms felt on waking caused by nocturnal hypotension
sectoral disc swelling and altitudinal field loss (top or bottom field loss)

32
Q

management of non-arteritic ischaemic optic neuropathy

A

vascular risk factors, avoid BP meds nocte (this may cause nocturnal hypotension)

33
Q

prognosis of non-arteritic ischameic optic neuropathy

A

VA remains status or improves slightly in majority
15% risk to fellow eye within 5 years

34
Q

optic neuritis on MRI

A

unilateral optic nerve looks thicker, wider, enhanced on MRI

35
Q

optic neuritis aetiology

A

immune mediated inflammation +/- demyelination (risk factor for multiple sclerosis)
younger patient
often preceding viral illness with neuropathic presentations

36
Q

presentation of optic neuritis

A

20-45 yo, recent viral illness
+/- neurological symptoms
known MS

37
Q

DDx of optic neuritis

A

idopathic, infective, inflammatory, autoimmune/demyelination

38
Q

management of optic neuritis

A

MRI brain/spine (T2 hyper intense lesions)
bloods +/- LP after neuroimaging to rule out infection
high dose steroids hasten recovery
immunomodulatory treatment

39
Q

prognosis of optic neuritis

A

90% improve to near normal VA in weeks
risk of development of MS (38% of MRI- and 56% of MRI+ at 10y)

40
Q

compressive tumours

A

gradual, progressive
Ddx: meningioma, pituitary adenoma, aneurysm, thyroid eye disease

41
Q

infiltrative issues

A

subacute - weeks/months
Ddx: lymphoma, leukaemia, multiple myeloma, carcinoma

42
Q

toxic/nutritional issues

A

gradual onset; social history is relevant
ethambutamol, amiodarone, alcohol, methanol, methotrexate, cyclosporine

43
Q

summary of conditions

A