Acute Viral Hepatitis Flashcards
1
Q
Cause of increased soluble, conjugated bilirubin in the blood?
A
mechanical blockage of biliary tract
2
Q
cause of increased unconjugated bilirubin in the blood?
A
dysfunction of hepatocytes
3
Q
When are AST and ALT increased in the blood?
A
if there is death of hepatocytes, they release their cytoplasmic proteins in the blood
4
Q
Changes in this hepatocyte?
A
- In Ballooning degeneration, Hepatocytes show cellular swelling (also called “cloudy swelling” or “hydropic degeneration”).
- This is a manifestation of sub-lethal cellular injury and results from dysfunction of ionic and fluid homeostasis in involved cells.
- Bilirubin (brown color on left)
5
Q
What happens in ballooning degeneration?
A
Edema with swelling of the endoplasmic reticulum (ER) and detachment of ribosomes from the rough ER.
6
Q
What type of necrosis is typical for viral hepatitis?
A
Lytic necrosis
7
Q
What type of cell changes are seen in these pictures?
A
Left: apoptosis (acidophil bodies)
Right: coagulative necrosis
8
Q
Differences between necrosis and apoptosis?
A
