Acute Renal Failure/ Acute Kidney Injury Flashcards
Goal of Acute kidney injury (AKI)
Minimize long term loss of renal function, prevent chronic kidney failure
Mgmt of AKI
- Replace renal function temporarily
- Minimize potentially lethal complications
- reduce potential causes of increased kidney injury
Common pt with AKI
Pts who are hospitalized or in outpatient settings
Acute kidney injury
- Occurring for under 7 days
- Rapid loss of renal function due to dmg to kidneys
- High mortality rate
Criteria for AKI
- 50+% increase in serum creatinine above baseline
- Urine volume: Normal or changes
- Non-oliguria
- Oligura
- Anuria
Normal urine output
1 mg/kg/hr
30 ml/hr is minimum
Nonoliguric
Normal, greater than 800ml/day urine output
Oliguria
Less than 0.5 ml/kg/hr of urine output
Anuria
Less than 50 ml per day of urine output
Normal creatinine
Depends on the hospital
* 0.8-1.2
* 0.6-1.4
Is AKI reversible
Yes
Reversible causes of AKI
- Hypovolemia
- Hypotension
- Reduced CO
- HF
- Obstruction of kidney or lower urinary tract by tumor, blood clot or kidney stone
- Bilateral obstruction of renal arteries or veins
First organ to be damaged if there is issues in the body
Kidneys , 25% of CO goes to the kidneys
First sign of AKI
Reduced urine output
Risk factors for AKI/ARF
- Major surgery
- Major trauma
- Nephrotoxic meds (IV contrast/mycin antibiotics)
- Elderly (Decreased renal function)
Categories of AKI: Prerenal
- Hypoperfusion to the kidneys
- Caused by
- HF, Decreased CO
- Bleeding
- Dehydration
- Impaired blood flow leading to hypoperfusion of kidney, decreased GFR (Renal artery stenosis)
Common causes of AKI: Pre-renal
- Volume depletion, burns, hemorrhage, GI loses (Vomiting, diarrhea, NG suction)
- Hypotension and vasodilation (Sepsis, shock , anaphylaxis)
- Impaired cardiac (Cardiogenic shock, dysrhythmias, HF, MI)
Categories of AKI: Infarenal
- Damage to the actual kidney
- Glomeruli or kidney tubules
Causes of AKI: Infrarenal
- Acute tubular necrosis Damage to the kidney tubules
- Hemoglobinuria vs hematuria
- Rhabdomyolysis/ myoglobinuria (Trauma, crush, injuries, burns)
- Infectious processes: Acute glomerulonephritis, acute pyelonephritis
Hemoglobinuria vs hematuria
- Slight differences but for the purposes for this exam, it’s just blood in the urine
Types of kidney injury
Prerenal
Intrarenal
Postrenal
Phases of AKI (IODR)
- Initiation: Initial insult to when oliguria occurs
- Oliguria period: Decreased urine output, can last 10-14 days
- Diuresis period
- Recovery period
Phases of AKI: Diuresis period
- Gradual increase in urine output
- GRF recovers
- Renal function: Still abnormal due to uremia
- Observe for dehydration
Phases of AKI: Recovery period
- Signals improvement in renal function (3-12 mo)
- Lab values return to normal level
- Permanent 1-3% reduction in GFR, not clinically significant, due to dmg
AKI Assessment and diagnostics findings
- Varies from scant to normal volume
- Hematuria
- Low specific gravity
- Renal sonogram/ MRI/ CT, can show anatomical differences
- BUN serum creatinine increased
- Decline in GFR, oliguria, anuria
- Hyperkalemia, may lead to dysrhythmias (VT) cardiac arrest
Normal specific gravity
1.010-1.025
Why is there hyperkalemia in AKI
Body cannot excrete it properly
AKI Assessment and diagnostics findings: metabolic acidosis
- Associated with decreased serum CO2 (Form of compensation)
- Decreased PH levels
AKI Assessment and diagnostics findings: Blood Phosphates
May be elevated, coming from nutrition
AKI Assessment and diagnostics findings: Calcium
- May be low due to decreased absorption of Ca in the intestine and due to increased blood phosphate
AKI Assessment and diagnostics findings: Anemia
- Erythropoietin is produced in the kidney, in AKI it is not produced leading to a decrease in WBC
If Ca increases what happens to P and Mg
- P decreases
- Mg increases
Ca and P are inversely related
Factors that influence mortality AKI
- Increased age
- Comorbid conditions (Diabetes and HTN)
- Pre-existing kidney and vascular diseases
- Resp failure
Best way to treat AKI
prevention