Acute Lymphoblastic Leukemias

Question 0

B cell

Answer 0

Most common
1. Pro B cell
2. Pre B cell (Common)
3. B cell ALL
4. Mature B (Burkitt's)
PAS (+)

Question 1

T cell

Answer 1

Less common, worse prognosis

PAS (+)

Question 2

T cell ALL

Answer 2

Most commonly found in older males and associated with mediastinal mass, has a higher incidence of CNS involvement, TdT positive

Question 3

Burkitt’s lymphoma

Markers, Stain, Gene Translocation, Morphology, Physical Assoc.

Answer 3

“Mature B cell Lymphoma”
Markers: CD19, CD22, CD20, CALLA NEGATIVE
Surface immunoglobulin (IgG)
TdT negative
C-MYC gene translocation t(8;14)
Deeply basophilic cytoplasm containing VACUOLES
Associated with Epstein-Barr virus, children present with jaw/facial bone tumors or an abdominal mass

Question 4

B cell ALL

Answer 4

Markers: CD19, CD20; SIg and CD10 NEGATIVE

Between Pre-B and Mature B (Burkitt’s) Lymphomas

Question 5

Pre B cell leukemia (Common ALL)

Markers, Stain, Frequency, Gene Translocation

Answer 5

Markers: CD34, CD10, CD19, CD20, CALLA POSITIVE
TdT positive
85% of cases available in children, and about 70% of cases in adults.
In adults, the Philadelphia chromosome maybe president

Question 6

Pro B ALL

Markers, Stain, Gene Translocation

Answer 6

Markers: CD34, CD38, CD19; NEGATIVE for SIg, CALLA, and CD20
TdT positive
Associated with t(4;11) translocation

Question 7

Sequence of B cell classification based on maturation

Answer 7

Pro-B, Pre-B, B cell ALL, Burkitts (Mature B)