Acute Kidney Injury Flashcards
What is acute kidney injury?
- Reduction in glomerular filtration rate resulting in azotemia developing over days
- Commonly due to renal ischemia or toxins
- Usually reversible
- Absence of symptoms of chronic uremia
- Kidney size usually preserved
What are the diagnostic criteria for acute kidney injury (AKI)?
An abrupt (within 48 hours) reduction in kidney function defined as:
• An absolute increase in serum creatinine level of 0.3 mg/dl, or
• A percentage increase in serum creatinine level of > 50% (1.5-fold from baseline), or
• A reduction in urine output < 500 ml in 24 hours
Why do we worry about severe AKI?
there are mild, moderate and severe forms of AKI. the mortality rate jumps in severe AKI especially when the pt requires dialysis.
What is oliguria?
urine output < 400-500 ml/day
What is azotemia?
elevation of nitrogen waste products related to insufficient filtering of blood by the kidneys
What is uremia?
the illness accompanying kidney failure which results from the toxic effects of abnormally high concentrations of nitrogenous substances in the blo`od
How are GFR and serum creatinine related?
Serum levels are inversely proportionate to GFR (GFR~100/Cr) and the relationship is not linear
What is Blood Urea Nitrogen (BUN)?
Nitrogenous waste product of protein metabolism- Less accurate indicator of GFR than creatinine due to variation in:
– protein intake
– catabolic rate
– tubular reabsorption
What are casts?
can be seen in urinalysis caused by trapping of cellular elements in a matrix of protein secreted by renal tubule cells
What kind of casts are seen in acute tubular necrosis?
Granular casts (“muddy brown urine”)
What is the range of BP in which autoregulation works the best to regulated GFR and RBF?
from 80 to 160 mmHg the kidney can keep blood flow relatively constant.
During decreased perfusion pressure, what substances act on the afferent and efferent vessels of the glomerulus?
prostaglandins increase dilation of afferent arteriole and angiotensin II constricts the efferent
What are few things that can inhibit vasodilation of afferent arteriole by prostaglandins?
age, NSAIDs and CKD
What are few things that can inhibit vasoconstriction by Ang II in the efferent arteriole?
ACEI and ARBs
What happens to autoregulation of GFR in normotensive ischemic AKI?
they cannot autoregulate at decreased perfusion pressure therefore the stable range of kidney blood pressure is decreased
What are the 3 AKI categories?
Pre-renal:Impaired effective renal perfusion without ischemic injury
Renal:Intrinsic renal disease (glomerular, tubular, interstitial, vascular)
Post-renal:Obstruction of urinary flow
What are some common causes of pre-renal AKI?
- Volume depletion
- Heart failure
- Liver failure
What are some common causes of renal AKI?
- Acute tubular necrosis
- Interstitial nephritis
- Glomerulopnephritis
- Vascular diseases
What are some common causes of post-renal AKI?
• Obstruction: Prostate Bladder Stones Tumors
In pre-renal AKI decreased perfusion causes increase in AngII and vasopressin, what does that do?
increased reabsorption of sodium (at proximal tubule) and water → concentrated urine = oliguria
Pre-renal AKI: urea is also retained what does that do to lab values?
elevation of BUN out of proportion to creatinine
What do we see on histology with pre-renal AKI?
normal tubular epithelium
What is renal AKI?
Acute injury involving the tubules, glomeruli, interstitium, or vasculature causing decreased GFR
What is the most common cause of renal AKI?
Acute tubular necrosis or ischemia/toxins
