Acute Fatty Liver

Question 1

What is the prevalence of AFLP

Answer 1

5:100,000

Question 2

Maternal mortality rate if aflp

Answer 2

Up to 18%

2% ukobs surveillance system study

Question 3

Fetal mortality rate if aflp

Answer 3

Up to 23%

11% UK OBS surveillance study

Question 4

What are the risk factors for AFLP (5)

Answer 4

• previous AFLP
• male fetus
• multiple gestation
• LCHAD mutation in fetus
• nulliparity

Question 5

What is the criteria used to diagnose AFLP

Answer 5

Swansea criteria

Question 6

What are the main aspects if the Swansea criteria (3)

Answer 6

• clinical symptoms
• biochemical
• radiological

Question 7

How many features of Swansea are required for aflp diagnosis

Answer 7

6 or more

Question 8

What is the basis of management of AFLP

Answer 8

• prompt delivery regardless of GA
• maternal stabilization in hdu

Question 9

What lab findings are associated with aflp (6)

Answer 9

• leucocytosis
• elevated creatinine
• elevated transaminase,uric acid, bilirubin
• elevated ammonia
• hypoglycemia
• prolonged prothrombin time

Question 10

What percentage of patients with aflp develop renal impairment

Answer 10

14%