Acute Care and Trauma and Mental Health Flashcards

1
Q

Acute Respiratory Distress Syndrome (ARDS)

A

Acute Lung injury caused by direct lung injury or occur secondary to severe systematic illness.

Lung damage and release of inflammatory mediators cause increased capillary permeability and non-cardiogenic pulmonary oedema, often accompanied by multi-organ failure.

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2
Q

ARDS

A

Acute and persistent lung inflammation with increased vascular permeability.

  • acute onset
  • bilateral Pulmonary infiltrates
  • hypoxaemia
  • non-cardiac
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3
Q

ARDS risk factors

A

Pulmonary:
pneumonia, gastric aspiration, injury

Other: sepsis, septicaemia, haemorrhage, burns/trauma, multiple transfusions, transplantation, drug overdose/reaction

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4
Q

ARDS history and exam

A

Rapid deterioration of respiratory function
Dyspnoea
Respiratory distress
cough

cyanosis
tachypnoa
tachycardia
Widespread inspiratory crepitations 
hypoxia refectory to oxygen treatment
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5
Q

ARDS Investigations

A

CXR: Bilateral alveolar and interstitial shadowing

Blood: FBC, U&E, Plasma BNP <100pg/ml may distinguish ARDS/ALI from heart failure, but if high BNP does not exclude either.

Echocardiography: May point to cardiac problem instead of ARDS

Pulmonary artery catheterisation: PCWP <18 mmHg

Bronchoscopy

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6
Q

Pulmonary infiltrate

A

Substance denser than air, such as pus, blood, or protein.

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7
Q

Alcohol dependence

A

3 or more of:

  • withdrawal on cessation of alcohol
  • tolerance
  • Compulsion to drink
  • Persistent desire to cut down or control use
  • Time is spent obtaining, using, or recovering from alcohol
  • neglect of other interest
  • continued use despite physical and psychological problems

common problem

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8
Q

Recommended limits for Females

A

14 units a week
(1 unit = 8 grams of alcohol)
1 glass wine or 0.5 pint of beer

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9
Q

Recommended limits for males

A

21 units a week
(1 unit= 8 grams of alcohol)
1 glass of wine or 0.5 pint of beer

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10
Q

Alcohol withdrawal

A

Alcohol enhances inhibitory GABA activity and inhibits excitatory glutamate transmission.
Chronic exposure results in compensatory reduction in GABA receptor function and up-regulation of the glutamate NMDA receptors.
ONLY the constant presence of alcohol preserves homeostasis.
Abrupt alcohol cessation leads to over-activation of the excitatory NMDA system relative to the GABA system.

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11
Q

Alcohol dependence history

A

Alcohol history: suggest drinking diary

CAGE screening questions:
Cut-down
Annoyed
Guilt 
Eye-opener
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12
Q

Acute alcohol intoxication

A
Amnesia 
Ataxia
Dysarthria
Disorientation
Palpitations
Flushing
Coma
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13
Q

Symptoms of withdrawal

A
Nausea
Sweating and tremor
Restlessness
Agitation
Visual hallucinations
Confusion
Seizures
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14
Q

Alcohol dependence exam

A

Signs of chronic alcohol abuse: Palmar erythema, bruising, spider naevi, facil mooning, gynacomastia

Signs of complication: Alcoholic hepatitis and liver failure

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15
Q

Alcohol dependence investigations

A

Blood:
Increased MCV, GGT, AST, ALT

Acute overdose: Blood alcohol, glucose, ABG, U&E, toxic screen

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16
Q

Management alcohol withdrawal

A
  • IV Vitamin B complex (Pabrinex)
  • Reducing doses of Chlordiazepoxide (benzo)
  • Close attention to dehydration, electrolyte imbalance, and infections
  • Nutritional support important as often malnourished
  • Lactulose and phospate enemas may help with encephalopathy
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17
Q

Alcohol withdrawal complications

A
Fits
Delirium tremens (48-72 hours after cessation - coarse tremor, agitation, fever, tachycardia, confusion, delusions, hallucinations)

Chronic complications: cerebral atrophy and dementia, cerebellar degeneration, optic atrophy, peripheral neuropathy

Indirect effects cause encephalopathy, thiamine deficiency leading to Wernicke’s encephalopathy or Korsakoff’s psychosis

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18
Q

Anaphylaxis

A

Acute life-threatening multi system allergic reaction.

Inflammatory mediators cause increased capillary permeability and decreased vascular tone, resulting in tissue oedema.

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19
Q

Common allergens leading to anaphylaxis

A
drugs (penicillin)
radiological contrast agents 
latex
insect stings 
egg
peanuts 
shell fish
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20
Q

Anaphylaxis history

A

Acute onset of symptoms on exposure to allergy:

  • wheeze, SOB, sensation of chocking
  • swelling of lips and face
  • Pruritus and rash

May have other hypersensitivity disorders (asthma, allergic rhinitis)

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21
Q

Anaphylaxis exam

A

Wheeze, cyanosis, tachypnea, swollen upper airways and eyes, rhinitis, rash

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22
Q

Anaphylaxis

A

Diagnosis clinically

After attack: Allergen skin testing

23
Q

Management of anaphylaxis

A
Stop any suspected drugs 
Resuscitation according to A,B,C
Secure airway and give 100% oxygen
Adrenaline IM 
Antihistamine IV 
Steroids IV 
IV crystalloid or colloid 
Treat bronchospasm with  salbutamol +/-ipratropium inhaler
Advice: How to use IM adrenaline pen and how to avoid allergen
24
Q

Anaphylaxis complications and prognosis

A

Respiratory failure, shock, death

Good prognosis if prompt treatment is given

25
Arterial blood gas
Used to determine gas exchange levels in the blood related to respiratory, metabolic, and renal function.
26
Indications of ABG
- to identify acid/base disorders, with or without compensation (may present with SOB, difficulty breathing, confusion, nausea) - Perform when suspecting kidney failure, heart failure, uncontrolled diabetes, haemorrhage, chemical poisoning, drug overdose, shock
27
ABG complications
Local hematoma Artery vasospasm Infection at puncture site feeling faint
28
Interpreting ABG
Step 1: Look at the pH Normal (7.35-7.45) >7.45 alkalaemia <7.35 acidaemia Step 2: Look at the PaCO2 Normal (4.7-6 kPa) >6 acidifying <4.7 alkalinising Align step 1 with step 2. If they both align then the problem is respiratory. E.G. Step 1: pH low Step 2: PaCO2 high =resp. acidosis Step 3: Look at the bicarbonate or base excess Base excess normal (-2 to +2) Bicarbonate normal (22-26 mmol/L) ``` E.G. pH low PaCO2 high Bicarb. high Respiratory acidosis, partially compensated ```
29
PH low & PaCO2 high
Respiratory acidosis Step 1 and step 2 align
30
pH high & PaCO2 low
Respiratory alkalosis | Step 1 and step 2 align
31
Aspirin overdose
Excessive ingestion of aspirin causing toxicity. | Ingestion of 10-20 grams causes moderate to severe toxicity in adults
32
Aspirin overdose
Increases respiratory rate and depth by stimulating CNS. Hyperventilation produces respiratory alkalosis in the early phase. Body compensates: Increase in urinary bicarbonate and K+ excretion -> dehydration and hypokalaemia Loss of bicarbonate together with build up of lactic acid lead to metabolic acidosis Severe: CNS depression and resp failure
33
Hyperventilation
Excess CO2 excretion -> hypocapnia | ->alkalosis
34
Aspirin Overdose epi. history exam
one of the most common drug overdoses Early: Flushed appearance, fever, sweating, hyperventilation, dizziness, tinitus, deafness Late: Lethargy, confusion, convulsions, drowsiness, respiratory depression, coma ``` exam: fever tachycardia hyperventilation epigastric tenderness ```
35
Aspirin overdose investigations
blood: salicylate levels in the blood, Potassium levels abg: may show metabolic acidosis and respiratory alkalosis ECG: hypokalaemia (small t waves, u waves)
36
Burns
1. Assess thickness (epidermis, partial, full thickness) 2. Assess Body surface area covered by burn 3. Assess location 4. Mechanism of injury
37
Epidural
Injection of a local anesthetic into the space outside the dura mater of the spinal cord in the lower back region to produce loss of sensation below the waist.
38
Epidural indication
Epidurals can be used during childbirth, including caesareans, during surgery, and after surgery
39
Epidural complications
``` Inadequate pain relief headache Nerve damage low BP loss of bladder control ```
40
Anxiety disorder
Excessive fear and worry, triggered by internal or external events, interferes with normal daily activity, and leads to impairment of functioning. Genetic factors play a role. Heritability estimated at approximately 30% co-morbidity with other anxiety disorders is common
41
Depressive disorders
Persistent sad, anxious, or empty mood Feelings of hopelessness or pessimism Feelings of guilt, worthlessness, or helplessness Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex Decreased energy, fatigue, being "slowed down" Difficulty concentrating, remembering, or making decisions Insomnia, early morning awakening or oversleeping Appetite and/or weight loss, or overeating and weight gain Thoughts of death or suicide, suicide attempts Restlessness, irritability Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders and chronic pain
42
Extradural Hemorrhage (epidural)
Suspect this if, after head injury, conscious levels falls or is slow to improve, or there is a lucid interval. - no loss of consciousness followed by decreasing loss of consciousness - After initial slight drowsiness seems fine
43
Lucid interval
Temporary improvement in a patient's condition after a traumatic brain injury, after which the condition deteriorates. Indicative of an Epidural haematoma
44
Extradural haemorrhage
May last a few hours to a few days before the bleed declares itself by decreased GCS from rising ICP. Increasingly severe headache, vomiting, confusion, and fits follow. (+/- brisk reflexes, up going plantars, hemiparesis) Bleeding continues: Ipsilateral pupil dilates, coma deepens, bilateral limb weakness develops, breathing deep and irregular (brainstem compression) Death follows a period of coma and is due to respiratory arrest.
45
Extradural haemorrhage
CT: Haematoma (round, lens-shaped) Skull x-ray: Looking for fractures (increases risk of EH massively) Lumbar puncture is contraindicated
46
Multi-organ dysfunction syndrome
Systemic, dysfunctional inflammatory response that requires long ICU stay and has a high mortality.
47
Sepsis
Spectrum from mild to severe: - SIRS - Sepsis - Septic Shock - MODS
48
Systemic Inflammatory Response Syndrome
``` 2 out: -Temperature >38 or <36 -Heart rate >90 -RR >20 or PaCO2 <32 (Normally 40) -WCC >12000 or <4000 or >10% band cells (immature WCC) ```
49
Sepsis
SIRS and confirmed infection
50
Septic Shock
Sepsis and hypotension that does not go away
51
MODS
Multiple Organ Dysfunction Syndrome Sever septic shock+ organ failure
52
Opiate Overdose
Opioid overdose triad: pinpoint pupils + unconsciousness+ respiratory depression Can lead to respiratory depression and death Combining opioids with alcohol and sedative medication increases the risk of respiratory depression and death
53
Risk factors for opioid use
- people with opioid dependence, in particular following reduced tolerance - people who also drink alcohol and sedative medication
54
Paracetamol overdose
- commonest overdose - first 24 hours asymptomatic - after 24 hours hepatic necrosis begins (elevated transaminases, RUQ pain, and jaundice) and can progress to acute liver failure