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DDS LAB > ACT 3& 4 > Flashcards

ACT 3& 4 Flashcards

1
Q

are semisolid preparations
intended for application to the skin.

They generally contain a larger proportion of solid material (such as 25%) than ointments and therefore are stiffer

A

Pastes

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2
Q

However, when a levigating agent is
to be used to render the powdered component smooth, a portion of
the base is often used rather than a
liquid, which would soften the paste.

A

NOTES RA

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3
Q

Preparation of Paste

A

-Direct mixing
-Use of heat

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4
Q

Use today:

A

Zinc Oxide Paste (Lassar’s Plain Zinc Paste)

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5
Q

semi-solid preparation intended for
topical application

A

Ointments

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6
Q

APPLICATION OF OINTMENTS

A
  • Skin
  • Surface of the eye
  • Nasally
  • Vaginally
  • Rectally
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7
Q

The unmedicated ones are used for their
physical effects as

A

protectants or lubricants

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8
Q

-delivered into the skin; treating dermal
disorders with the skin as the target organ

A

Local effects

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9
Q
  • consideration for pregnant women and
    nursing mothers
    Example: *Transdermal product**
A

Systemic effects

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10
Q

A __________________ is designed to deliver
drug into the skin in treating dermal disorders, with the skin as the target organ.

A

topical dermatological product

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11
Q

A ________________ is designed to deliver drugs through the skin (percutaneous absorption) to the general circulation
for systemic effects, with the skin not being the target organ.

A

transdermal product

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12
Q

semisolid preparations for external application to the skin or mucous membranes

-may be medicated or not

A

OINMENTS

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13
Q

-used for physical effects (protectant,
emollients, lubricants)

A

Unmedicated ointments

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14
Q

-used for physical effects or as vehicles for medicated ointments

A

Ointment base

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15
Q

OINTMENT BASES

A

a. Oleaginous bases
b. Absorption bases
c. Water-removable bases
d. Water-soluble bases

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16
Q
  • termed as hydrocarbon bases
  • emollient effect
  • protect against the escape of moisture
  • effective as occlusive dressing
  • remain on the skin for long periods without drying out
  • immiscible with water (difficult to wash off)
  • water and aqueous prep may be
    incorporated but only in small amounts and with some difficulty

-Levigation is commonly used in small-scale
preparation of ointments and suspensions
to reduce the particle size and grittiness of the added powders.

A

OLEAGINOUS BASES

17
Q

OLEAGINOUS BASES
Example:

A
  • Petrolatum
  • white petrolatum,
  • white ointment
  • yellow ointment
18
Q

In oleaginous bases, when powdered substances are to be incorporated into hydrocarbon bases, ____________ (mineral oil) may be used as the levigating agent

A

liquid petrolatum

19
Q

is commonly used in small-scale
preparation of ointments and suspensions
to reduce the particle size and grittiness of
the added powders.

A

Levigation

20
Q

These bases may be used as
emollients, although they do not
provide the degree of occlusion
afforded by the oleaginous bases.

-are not easily removed from the skin with water washing, because the external phase of the emulsion is oleaginous

A

Absorption bases

21
Q
  • those that permit the incorporation of
    aqueous solutions     resulting in the
    formation of water in oil (W/O) emulsions
    (e.g., hydrophilic petrolatum)

-those that are W/O emulsions (syn:
emulsion bases) that permit the
incorporation of additional quantities of aqueous solutions
(e.g., lanolin)

-This is accomplished by incorporating the
aqueous solution into the absorption base
and then incorporating this mixture into the hydrocarbon base.

-are useful as pharmaceutical adjuncts to incorporate small volumes of aqueous solutions into hydrocarbon bases.

A

Absorption Bases

22
Q

are oil-in-water emulsions
commonly called creams

  • Because the external
    phase of the emulsion is aqueous, they
    are easily washed from skin and are
    often called water-washable bases.
  • They may be diluted with water or aqueous solutions.
  • They can absorb serous discharges.
    Hydrophilic Ointment    , USP, is an
    example of this type of base.
A

WATER-REMOVABLE BASES

23
Q

do not contain oleaginous components

They are completely water washable and often referred to as greaseless
Because they soften greatly with the addition of water, large amounts of
aqueous solutions are not effectively incorporated into these bases.

-They mostly are used for incorporation of solid substances.
Polyethylene glycol (PEG) ointment, NF, is the prototype example of this base.

A

Water-soluble bases

24
Q

SELECTION OF THE APPROPRIATE BASE

A
  • Desirability of topical or percutaneous drug absorption.
  • Desired release rate of the drug substance from the ointment base.
  • For example, an ointment is generally
    applied to dry, scaly skin; a cream is
    applied to weeping or oozing surfaces;
    and a lotion is applied to intertriginous
    areas or where friction may occur, as
    between the thighs or under the armpit.
    The base that provides the best combination of the most desired attributes should be selected.

-Desirability of occlusion of moisture from the skin

-Stability of the drug in the ointment base
Effect, if any, of the drug on the consistency
or other features of the ointment base

25
Q

WHAT ARE THE TWO PREPARATION OF OINTMENTS?

A
  • Incorporation
  • Fusion
26
Q

The components are mixed until a uniform preparation is attained

A

Incorporation

27
Q

-By this method, all or some of the components of an ointment are combined by being melted together and cooled with
constant stirring until congealed.

A

Fusion

28
Q

WHAT ARE THE COMPENDIAL REQUIREMENTS FOR OINTMENTS

A
  • Microbial content
  • Minimum Fill
29
Q
  • With the exception of ophthalmic
    preparations, topical applications are not
    required to be sterile

-They must, however, meet acceptable
standards and preparations prone to microbial growth must contain antimicrobial preservatives.

-Preparations that contain water tend to support microbial growth to a greater extent than water-free preparations.

-Among the antimicrobial preservatives used to inhibit microbial growth in topical
preparations are methylparaben,
propylparaben, phenols, benzoic acid, sorbic acid, and quaternary ammonium salts.

A

Microbial content

30
Q

USP’s ________________ test that
determines the net weight or volume of the contents of filled containers to ensure proper contents compared with the labeled
amount.

A

Minimum Fill

31
Q

What are the antimicrobial preservatives used to inhibit microbial growth in topical
preparations?

A
  • methylparaben,
  • propylparaben
  • phenols
  • benzoic acid
  • sorbic acid
  • quaternary ammonium salts.

DDS LAB (5 decks)

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