Acquired Immune Response Flashcards
Helps regulate T-lymphocytes.
Major histocompatibility complex (MHC) products
Old name of MHC
Human leukocyte antigen (HLA)
The specific immune response to parasites begins processed by
CD4 T-helper Lymphocytes.
What is the subsets of CD4 T-Lymphocyte?
Th1 and Th2
Th1 lymphocytes produce
Gamma interferon
Interleukin-2
Macrophage
What subset of t-helper cell mediates cell-mediated immune response?
Th1 lymphocyte
Th1 acitivates____ through gamma interferon and interleukin-2
Cytotoxic lymphocytes
T or F
Parasitic-specific antigen induces clonal expansion of parasite-specific T-Lymphocyte .
True
Cell mediated immunity may act by
- Direct cytotoxicity
- Indirectly on natural killer cells
Migrating larvae of ____ are killed through cell-mediated activity.
Toxocara canis
What is the product of Th2?
Interleukins 4,5,6
It enhances the proliferation and differentiation of B lymphocyte into plasma cells.
4,5,6 interleukins
Responsible for immunoglobulin production.
B-lymphocyte
In Helminths infections, the mkst common responses includes____.
Eosinophilia and elevated serum IgE.
Lumen dwelling helminths.
Ascaris lumbricoides
Trichuris trichiura
Lymphatic dwelling helminths
Wuchereria bancrofti
Brugia malayi
This antibody is bound in mast cells, Eosinophil, and gobket cells. They can mediate the eventual expulsion of adult gastrointestinal helminths.
IgE
This immunoglobulin invloves in inflammatory, cytotoxic action
IgE
What is the indication of increasing eosinophil?
Hypersensitivity/ allergic reaction
Parasitic infection
It is an antibody dependent cell-mediated cytotoxicity (ADCC)
IgE
There are a variety of activating molecules expressed by the eosinophil that mediates (ADCC)
What are they?
Eosinophil activating factor (EAF)
Interleukin-5
Granulocyte monocyte colony stimulating factor (GM-CSF)
Destruction of microfilariae has been attributed to ADCC mediated by___.
IgE and eosinophil
Aside from IgE and eosinophil, what else are involved in ADCC?
Neutrophils and platelets
They can act on mast cells and basophils, which lead to degranulation and eventual release of pharmacologically active substances.
Homocytotrophic IgG1 and IgE
Unregulated activation can results in ___.
Anaphylactic Type 1 hypersensitive
Rupture of echinococcus granulosus hydatid cyst.
Type 1 hypersensitivity
The combine activity of ____ can prevent penetration of erythrocytes by Plasmodium spp. And Babesia spp.
IgG and IgM
Combine activity of IgG and IgM can is effective against gastrointestinal helminths.
False - ineffective
The complement activity of these immunoglobulin can mediate lysis of trypomastigotes of Trypanosoma cruzi.
IgG and IgM
The secretion of this immunoglobulin in the intestine protect agaisnts metacestode and GI infections.
IgA
IgM and IgA mediate…
ADCC in Giardia lamblia infection
Cryptosporidium infection is self limited due to the combined action of ___.
IgA ans IgG with cell mediated immunity
T or F
The host can activate its non-specific, specific, humoral, and cell-mediated defenses all at the same time.
True
