Acne and rosacea Flashcards
Inflammatory Disease of the Pilosebaceous Unit
acne
pathogenesis of acne (4)
- sebaceous gland hyperplasia with ceborrhea
- altered follicular growth and differentiation
- colonization of probionibacterium acnes
- inflammation and immune response
which hormone causes sebaceous gland hyperplasia
androgens
abnormal follicular desquamation
keratinocytes hyperproliferate and are not shed as normal leading to densely packed along with lipid droplets in the inner follicle
clogged hair follicle / keratinocytes
comedo
No correlation between reduction of P. acnes and the clinical improvement of acne
yep
CD4 lymphocytes invade follicular wall leading to disruption
last step of acne formation- inflammation and immune response
comedonal acne vulgaris
only comedones no inflammatory process
medication for
normalize follicular desquamation and some reduce inflammatory response
topical retinoids
menidcations:
reduce microorganisms and some reduce inflammatory response
antibiotics
medication:
reduces microorganisms
benzoyl peroxide
medication:
reduces sebum production, normalizes follicular dequemetion, reduces P. acnes indirectly and reduces inflammation
oral isotretinoin
medications:
reduces sebum production and normalize follicular dequemation
hormones
Topical retinoids should always be used for treatment
yep
why is tetracycline such a good systemic antibiotic for acne
antibiotic properties and reduces inflammatory processes