Acid-Base Physiology DSA Flashcards
What is an acid?
proton donor
What is a base?
proton acceptor
What is a strong acid?
completely or almost completely dissociated into a hydrogen ion and its conjugate base in dilute aqueous solution
What is hydrogen ion activity in pure water?
10^-7
arterial oxygen PaO2
80-100 mm Hg (age dependent)
arterial carbon dioxide PaCO2
35-45 mm Hg (use 40 mm Hg)
arterial pH (pHa)
7.35-7.45 (use 7.4)
arterial bicarbonate (HCO3-)
22-26 mEq/L (24 mEq/L)
acidosis
pH<7.35
alkalosis
pH>7.45
What effect does increased HCO3 have on pH?
increases pH
What do the kidneys do to bicarbonate?
move to urine and reabsorb, along with secreting H+ to urine
What does GI do to HCO3?
secretes it and H+
What will vomiting and diarrhea cause to HCO3 levels?
decrease
Do anti-acids, lactic acid, lactate, and ketoacids change HCO3?
yes
What are metabolic disturbances?
changes in HCO3
What is the balanced CO2/HCO3 equation?
CO2+H2O->H2CO3->H+ + HCO3
How will increased CO2 change pHa?
lowers –> acidosis
How will decreased CO2 change pHa?
increases –> alkalosis
What is a respiratory disturbance in acid-base balance?
Anything that alters CO2 movement from the alveoli to the blood
increased HCO3
metabolic increased pH (alkalotic)
decreased HCO3
metabolic decreased pH (acidic)
increased CO2
respiratory decreased pH (acidic)
decreased CO2
respiratory increased pH (alkalotic)