acid base balance Flashcards
what overcomes reduction of pH in body?
rbcs
buffers in bf
brain liver kidney
pH =
6.1 + log ( HCO3/(0.03 x PCO2))
anion gap represents what?
unmeasured anions = lactate acetoacetate and albumin
AG equation without K ref range
8-16 mmol / L
AG equation with K ref range
12-20 mmol / L
AG equation
( Na + K ) - ( Cl + HCO3)
what makes up 1-2 % of total Hb in blood?
COHb and MetHb
what is the ketone body that is in greatest proportion in the blood?
beta hydroxybutyrate
whats an iatrogenic source of base?
HCO3-
what is the buffer system in highest concentration in the blood plasma?
HCO3 CO2 –> carbonic acid
whats an imp intracellular buffer?
phosphate
how does kidney respond to acidemia?
production of ammonia
if anion gap >20 then
very likelihood primary metabolic acidosis regardless of pH and HCO3
excess ag equation
(AG - normal AG ) + [ HCO3]
if sum is greater than upper limit of normal [HCO3] then metabolic alkalosis if sum less than lower limit of normal [HCO3] metabolic acidosis ref range of [HCO3] = 22-29