Aciclovir

Question 1

Give 3 examples of antivirals.

Answer 1

Aciclovir
Famciclovir
Valaciclovir

Question 2

What is the mechanism of action of antivirals?

Answer 2

They prevent viral DNA replication by competing with the natural substrates to be incorported into the viral DNA, stopping replication

Question 3

What are the indications for aciclovir?

Answer 3

Herpes simplex infection
Post-exposure prophylaxis of varicella zoster
Treatment of varicella zoster

Question 4

What are the contraindications for aciclovir?

Answer 4

Renal impairment and eldery (reduce dose)

Question 5

Is aciclovir safe in pregnancy and breastfeeding?

Answer 5

Not known to be harmful but manufacturer advises caution

Question 6

What does aciclovir interact with?

Answer 6

Theophylline and aminophylline - aciclovir increases plasma concentration of these drugs

Question 7

What are the common side effects of antivirals?

Answer 7

GI disturbance
Headache

Question 8

What are the important side effects of antivirals?

Answer 8

Neurotoxicity
Acute renal failure

Question 9

What is important to tell patients taking antivirals?

Answer 9

Stay adequately hydrated to help prevent neurotoxicity symptoms

Complete whole course of medication even if they start to feel better

Question 10

What class of drug is aciclovir?

Answer 10

Antiviral