ACEi - van Rijn Flashcards
1
Q
What cells release renin and where are they located?
A
Juxtaglomerular cells; kidney
2
Q
What 3 things cause renin release?
A
- Drop in BP (<90 systolic)
- Low NaCl in distal tubule of the kidney
- Activation of beta 1 adrenergic receptors
3
Q
What does renin lead to formation of?
A
angiotensin II
4
Q
How does angiotensin II raise BP?
A
- Stimulates the adrenal cortex to release aldosterone
- Constriction of smooth muscle
- Activates thirst center
- Modulate baroreceptor reflex
- Causes cardiovascular hypertrophy
5
Q
How do you indirectly inhibit renin release?
A
- Loop diuretics
- Beta 1 blockers
6
Q
How do you directly inhibit renin release?
A
-Renin inhibitor
7
Q
Which ACE inhibitor is most commonly used?
A
Lisinopril
8
Q
Which ACE inhibitor can cause a rash?
A
Catopril
9
Q
Which ACE inhibitor is a prodrug?
A
Enalapril
10
Q
Which antihyptertensive reduces the risk of gout?
A
ARBs (-sartans)
