ACE Inhibitors and ARBs Flashcards
1
Q
Only ACEi 100% Renally excreted (no hepatic metabolism)
A
Lisinopril
2
Q
Clinical Effects of ACEi and ARB
A
Vasodilation Decrease catecholamine sensitivity Decrease Aldosterone Release Decrease ADH Release Decrease Na+/H+ Exchange in proximal tubules (Increasing Na+ excretion) Decreased Sensation of Thirst
3
Q
Unique Side Effects of ACE Inhibitors
A
Angioedema
Cough
4
Q
Side Effects of ACE Inhibitors and ARBs
A
Hypotension
Hyperkalemia
Angioedema, Cough (ACEi only due to bradykinin synthesis)
5
Q
Contraindications of ACE Inhibitors and ARBs
A
Pregnancy
Potassium Sparing diuretics
Severe CKD