ACE 2014-11B Flashcards

0
Q

Most prominent side effect of cisplatin

A

Renal toxicity

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1
Q

Disorder of pregnancy with severe hypoglycemia and elevated serum ammonia levels.

A

Acute fatty liver of pregnancy

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2
Q

Most prominent side effect of vincristine

A

Neurotoxicity

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3
Q

Most prominent side effect of cyclophosphamide

A

Myelosuppression

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4
Q

Most prominent side effect of bleomycin

A

Pulmonary toxicity

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5
Q

Anatomic reference point of zero for transducer for a lumbar CSF drain

A

External auditory meatus

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6
Q

Omphalocele or gastroschisis is associated with congenital cardiac anomalies

A

Omphalocele

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7
Q

FRC is how many mL per kg?

A

30 mL/kg

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8
Q

Risk of meconium stained amniotic fluid is related to gestational age and birth weight in proportion or inverse proportion

A

Proportion

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9
Q

Recommendations for presence of meconium stained amniotic fluid in a vigorous term neonate

A

No intervention required

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10
Q

Most likely clinically significant electrolyte abnormality to occur with prolonged infusion of oxytocin

A

Hyponatremia because of water retention from the vasopressin-like anti diuretic actions of oxytocin

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11
Q

How does increased gastric pH affect the GI absorption of methadone?

A

Increases (eg patient taking a PPI will have increased plasma methadone levels)

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12
Q

Glycine is inhibitory or excitatory neurotransmitter?

A

Inhibitory

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13
Q

Glutamate is inhibitory or excitatory neurotransmitter?

A

Excitatory

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14
Q

Chassaignac tubercle is at what cervical level?

A

It’s the C6 transverse process.

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15
Q

First rib, lung apices usually are located at what cervical level

16
Q

Stellate ganglion lies on what border of the longus colli muscle

A

Lateral border

17
Q

Suprascapular nerve originates from which nerve roots?

A

C5-6 with variable contribution from C4

18
Q

Nerve that innervates supraspinatus and infraspinatus muscles

A

Suprascapular nerve

19
Q

Three parts to evaluating postoperative respiratory function in patient undergoing lung resection

A
Respiratory mechanics (FEV1)
Gas exchange (DLCO)
Cardiopulmonary function (VO2 max)
20
Q

Climbing 2 flights of stairs corresponds to what VO2 max?

A

12 mL/kg/min

21
Q

Manifestation of acute acetaminophen overdose in the first 24 hours

A

Nausea/vomiting, abdominal pain, pallor, diaphoresis, fatigue

22
Q

Primary treatment for acetaminophen toxicity

A

N-acetylcysteine, which increases synthesis of glutathione which is essential to detoxification of acetaminophen

23
Q

How are the effects of nondepolarizing neuromuscular blockade changed when a patient has burns on more than 30% of body surface

A
Decreased sensitivity (larger dose needed)
Prolonged onset of action 
Shortened duration of action
24
Methemoglobin shifts oxyhemoglobin dissociation curve in what direction
Left
25
Sulfhemoglobin shifts oxyhemoglobin dissociation curve in what direction
Right
26
What's the antidote for sulfhemoglobin?
None, elimination of sulfhemoglobin occurs with the destruction of the red blood cell
27
Pain relief from codeine comes from metabolism of codeine to what?
Morphine
28
Codeine is metabolized by what enzyme?
P450 enzyme, specifically cytochrome CYP2D6
29
Medications that are best known as CYP2D6 inhibitors
SSRI (fluoxetine, paroxetine), diphenhydramine, bupropion.
30
Medications that are best known as CYP2D6 inducers
Dexamethasone, rifampicin.
31
Antibiotics that prolong neuromuscular blockade
Aminoglycosides, penicillins, polymyxins, bacitracin
32
Proposed mechanism for prolonged neuromuscular blockade by aminoglycosides
Decreased release of acetylcholine: 1) competition with calcium 2) modification of prejunctional membrane
33
Bier block is safer with lidocaine or prilocaine
Prilocaine