ABX: Spectrum, Uses Flashcards
Spectrum of Activity: Narrow Spectrum/Natural Penicillins
- *narrow, mostly G+**
- Strep, Enterococcus
- N. meningitidis
- Peptostrepto, Clostridium
- Treponema pallidum, Listeria
Spectrum of Activity: Penicillinase Resistant/Anti-Staph Penicillins
- *narrow, mostly G+**
- MSSA, Streptococcus, MSSE
- Peptostrepto
Spectrum of Activity: Amino-Penicillins
- *extended spectrum**
- Strep and Enterococcus
- H. flu, Neisseria, Proteus
- Peptostrepto, Clostridium
- Listeria, H. pylori
Spectrum of Activity: Amino-Penicillins w/ Beta-lactamase Inhibitor
- *adds coverage for Staph, M. cat, E. coli, Klebsiella, B. frag**
- Strep, Entero
- H flu, Neisseria, Proteus
- Peptostrepto, Clostridium
Spectrum of Activity: Anti-Pseudomonal Penicillins
- *similar to amino-pens, but add Pseudomonas**
- Staph, Strep, Entero
- H. flu, Neisseria, Proteus, M cat, E coli, Klebsiella, Proteus
- Peptostrepto, Clostridium
Spectrum of Activity: Anti-Pseudomonal Penicillins w/ Beta-lactamase Inhibitor
- *adds coverage for Serratia, Enterobacter, B. frag**
- Staph, Strep, Entero
- H. flu, Neisseria, Proteus, M cat, E coli, Klebsiella, Proteus
- Peptostrepto, Clostridium
Spectrum of Activity: Cephalosporins
1st gen: G+ , G- **
2d gen: G+ **, G- **
3rd gen: G+ , G- **
Spectrum of Activity: Carbapenems
- *broad spectrum ICU coverage**
- Staph, Strep
- good G- including Pseudomonas
- good anaerobes except C diff
- no coverage MRSA, DRSP, VRE, Enterococcus, atypical pneumonia
Spectrum of Activity: Monobactams
- *Gram negative specialist**
- good activity against gram neg anaerobes, including Pseudomonas
Spectrum of Activity: Vancomycin
- *Gram positive specialist**
- very active against Staph, HCA-MRSA, MRSE, Strep, Enterococcus
- no gram neg coverage
Spectrum of Activity: FQs
- Ciprofloxacin (2nd gen) is best pseudomonal
- Levofloxacin (3rd) is better resp FQ than cipro
- Moxifloxacin (4th) is best resp FQ, only one w/ B. frag activity
- all cover: chlamydia, legionella, mycoplasma, mycobacterium TB, H pulori
Spectrum of Activity: TMP/SMX
- *varied**
- Strep pneumoniae, Staph
- H flu, M cat, E coli, Klebsiella, Serratia
- GI: Enterotoxigenic E coi, Salmonella, Shigella, Vibrio cholerae, Yersinia
- Listeria, Nocardia, Mycobacterium marinum
- Pneumocystis (carinii) jiroveci
Spectrum of Activity: Aminoglycosides
- *good gram neg activity including Pseudomonas**
- tobramycin best for pseudomonas (Toby goes with Sue)
- gentamicin best for serratia (Gent goes with Serra)
Spectrum of Activity: Tetracyclines
- *broad spectrum bacteriostatic drugs**
- inhibit many gram + and - organisms
- rickettsiae, spirochetes, mycoplasmas, chlamydiae, borrelia burgdorferi
Spectrum of Activity: Macrolides
- Erythro: varied G+, ok G-, Clostridium, mycoplasma/legionella/chlamydia species, Bordetella pertussis, Treponem, Campylobacter jejuni
- Clarithro: same as erythro but add toxoplasma gondii, borreli burgdorferi, babesia microti
- Azithro: broader spectrum; improved H flu; Peptostrepto and Clostridium; M and C pneumoniae, Treponema, N. gonorrhea, Chlamydia trachomatis
