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Fall2014 - Pharm ID/Pulm > ABX: MOA, MOR, Classes > Flashcards

ABX: MOA, MOR, Classes Flashcards

1
Q

Which antibiotic classes inhibit cell wall formation?

A
  • penicillins
  • cephalosporins
  • carbapenems
  • monobactams
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2
Q

MOA of Vancomycin

A

inhibits cell wall formation at earlier step than beta-lactams

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3
Q

MOA of Fluoroquinolones

A

inhibit topoisomerases and DNA replication

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4
Q

MOA of TMP/SMX

A

-inhibit DNA, RNA, protein synthesis (blocks folate pathway)

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5
Q

Which antibiotic classes inhibit protein synthesis at the ribosomes?

A
  • aminoglycosides
  • tetracyclines
  • clindamycin
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6
Q

MOA of Macrolides

A

-inhibit RNA-dependent protein synthesis

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7
Q

MOA of Metronidazole

A

-reactive metabolites damage DNA

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8
Q

Mech of Resistance of Penicillins

A
  • beta lactamase

- altered penicillin binding proteins (PBPs)

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9
Q

Mech of Resistance of Cephalosporins

A
  • beta lactamase

- altered penicillin binding proteins (PBPs)

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10
Q

Mech of Resistance of Carbapenem

A

antagonism with other beta lactams

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11
Q

Mech of Resistance of Vancomycin

A

-VRE/VRSA

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12
Q

Mech of Resistance of Fluoroquinolones

A
  • efflux pump
  • gene mutations
  • decreased permeability
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13
Q

Mech of Resistance of TMP/SMX

A

gene mutations

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14
Q

Mech of Resistance of Aminoglycosides

A
  • inactivation by enzymes

- decreased binding/uptake

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15
Q

Mech of Resistance of Tetracyclines

A
  • decreased permeability
  • efflux pump
  • altered PBPs
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16
Q

What are the classes of penicillin antibiotics?

A

-Narrow spectrum/natural
-Penicillinase-resistant penicillins (anti-staph)
-Extended Spectrum:
Amino-penicillins (+ beta-lactamase inhibitors)
Anti-pseudomonal penicillins (+/- beta-lactamase inhibitors)

17
Q

What are the classes of cephalosporin antibiotics?

A

1st-3rd generations

18
Q

What are the classes of fluoroquinolone antibiotics?

A

1st-4th generations

19
Q

What are the classes of macrolide antibiotics?

A
  • Azithromycin
  • Clarithromycin
  • Erythromycin
20
Q

Penicillin General Structure

A

-garage and house structure

beta lactam ring and 5 side thiazolidine ring

21
Q

Cephalosporin General Structure

A

-garage and house with a porch

beta lactam ring and 6 side dihydrothiazine ring

22
Q

Carbapenem General Structure

A

-garage and house w/ attic and clothesline

beta lactam ring and 5 side carbapenem ring with long chain coming off the attic

23
Q

Fluoroquinolone General Structure

A

-3 hexagonal rings

Fall2014 - Pharm ID/Pulm (10 decks)

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