Abx & Friends Flashcards
Mnemonic
The Queens Guidance Counsellor Finds Abx Can Protect Large Royal Members
- tetracyclines
- fluoroquinolones
- glyco/lipopeptides
- cephalosporins
- folate antagonists
- aminoglycosides
- carbapenems
- penicillins
- lincosamides
- rifampin
- metronidazole
Gram coverage of tetracyclines
+/-
Name one tetracycline and what it can treat
Doxycycline - chlamydia trach., Treponema pallidum, MRSA
PO/IV
Name some contraindications or adverse effects for tetracyclines
Do not use with penicillins
AEs: teeth discoloration, photosensitivity
What is the gram coverage of Fluoroquinolones
+/-
What are some AEs of fluoroquinolones
tendon ruptures, QT prolongation
Name some examples of a fluoroquinolone and what they treat
Levofloxacin (pneumonia), Ciprofloxacin (enteric, pseudomonas, Neisseria)
PO/IV
Name some AEs of glyco/lipopeptides
Infusion reactions, “red man” syndrome
What is the gram coverage of glyco/lipopeptides
+
Name an example of a glyco/lipopeptide and what it can treat
Vancomycin (s. aureus, MRSA, MRSE, C. diff)
PO/IV
What is the gram coverage of cephalosporins
+/- (increasing negative coverage with higher generations)
What are some AEs of cephalosporins
allergies, red stools, biliary sludge
Name some examples of each generation of cephalosporin and what they can treat
1: cephalexin (PO), cephazolin (IV) - E. coli, Kleibsiella
2: Cephaclor (PO) - Neisseria
3: Ceftriaxone (IV), Cefdinir (PO) - gonorrhea, meningitis
4: Cephapine (IV) - pseudomonas aeruginosa
5: Cefteroline (IV) - MRSA
Name an AE of folate antagonists
steven’s johnson’s syndrome
What is the gram coverage of folate antagonists
+/-
What is an example of a folate antagonist
Sulfamethoxazole/Bactrim
PO/IV
What is an adverse effect of aminoglycosides
ototoxicity, nephrotoxicity
What is an example of an aminoglycoside and what can it treat
Gentamycin (IV) - pseudomonas, pneumonia
What is the gram coverage of aminoglycosides
-
What is an adverse effect of carbapenems
seizures
what is the gram coverage of carbapenems
+/-
What are some examples of carbapenems
Meropenem (IV)
Imepenem (IV) - broadest coverage
What are some side effects of penicillins
allergy, rash, diarrhea
what is the gram coverage of penicillins
+/-
What are some of the classes of penicillins and some examples
Natural: PCN G (IM), PCN V (PO) - Neiserria meningitides, treponema pallidum
Amino: Amox/Clav (PO), Amp/Sulb (PO) - E. coli, salmonella, anaerobes
Pseud: Pip/taz (IV): pseudomonal
What is an adverse effect of macrolides
QT prolongation
What is the gram coverage of macrolides
+
What is an example of a macrolide and what it treats
Azithromycin (PO/IV) - atypicals, chlamydia, legionella
What is an adverse effect of lincosamides
increased C. diff risk
What is the gram coverage of lincosamides
+
Name a lincosamide and what it can treat
Clindamycin (PO/IV) - anaerobes, MRSA
What is the gram coverage of Rifampin
+/-
What is an AE of rifampin
orange/red body fluids
What is the gram coverage of metronidazole
+/-
What is an adverse effect of metronidazole
dark urine
What can metronidazole treat
PO/IV
anaerobes, protozoals: giardia, trichomonas
What are some biologic/Kinase inhibitor DMARDs
Humira/adalimumab, Enbrel/etanercept (TNF-a inhibitors)
sub-q
What is an example of a traditional DMARD
methotrexate (PO)
Name a glucocorticoid and its route
prednisone (PO)
name some non-opioid pain agents
acetaminophen, aspirine, duloxetine (SSNRI), gabapentin (delta ligands)
name some opioid pain meds
hydrocodone-acetaminophen (Vicodin), oxycodone (oxycontin)
name some NSAIDs
diclofenac, ibuprofen, indomethacine, toradol, naproxen
name some muscle relaxers
cyclobenzaprine, diazepam
name some gout meds
allopurinol (nonselective), colchicine (antigout)
what would you likely use to treat osteomyelitis
Fluoroquinolones (no residual infected bone = 2-5 days PO, residual infected bone = 6 weeks PO, hardware = 6 weeks IV then 12 weeks PO)
Would you use PO or IV vancomycin for MRSA
IV because PO isn’t as bioavailable
Name some drugs with high oral bioavailability
Clindamycin, Metronidazole, Fluoroquinolones, Doxycycline, Oxazolidinones, Rifampin
What would you use empirically for osteomyelitis or infected prosthetic joints (IV)
Vancomycin (for MRSA) + Cefepime (3/4th gen ceph for gram -)
What would you use to treate septic arthritis empirically (IV)
Vancomycin (gram+) + Cefepime (Gram-), + Gentamicin or cipro (pseudomonas)
What would you use for all open fractures emperically (IV)
Cefazolin and vancomycin (add coverage for contaminations)
Directed IV therapy for MSSA infection
nafcillin, oxacillin, or cefazolin
Directed IV therapy for MRSA infection
Vancomycin or daptomycin
Directed IV therapy for strep infection
PCN G, ampicillin, ceftriaxone, or vanco
directed IV therapy for gram- infections
ciproflox, levoflox, ceftazidime, cefepime, ertapenem, meropenem
Directed IV therapy for enterococcus
pcn G, ampicillin, vanco, dapto
Directed PO therapy for MSSA infection
dicloxacillin, cefadroxil, cephalexin
Directed PO therapy for MRSA
smx-tmp, doxycycline, clindamycin