Abnormal Flashcards
BP I vs ADHD in adolescents
BP only Sx: Grandiosity Elation Flight of ideas Decreased need for sleep Hypersexuality
ODD vs Disruptive Mood Dysregulation disorder
Disruptive Mood is more severe, frequent and chronic
Opioids intoxication
Drowsiness or coma
Slurred speech
Impaired attention/memory
Opiod withdrawal
Dysphoric mood Nausea/Vomiting Muscle aches Lacrimation or rhinorrhea Pupillary dilation, piloerection (hair), or sweating Diarrhea Yawning Fever Insomnia
Cannabis intoxication
Increase appetite
Dry mouth
Tachycardia
Stimulant withdrawal
Fatigue vivid dreams Increased appetite Insomnia/hypersomnia Psychomotor agitation
PTSD Sx Clusters
Intrusion
Avoidance
Cog and mood
Arousal and reactivity
LD comorbidity with ADHD
20-30% have ADHD
Inhalant intoxication
Dizziness Nystagmus In coordination Slurred speech Unsteady gait Lethargy Depressed reflexes Tremor Blurred vision Euphoria Muscle weakness
Schizoid vs Schizotypal
Schizoid=NO cog/perceptual distortions
No friends bc no intimacy
“Oh, don’t get intimate with me”
SchizoTYPAL= eccentric, cog/perceptual distortions
No friends bc fear of people
“ODD Type”
Substance use disorder
Impaired control
Risky use
Pharm criteria
Social impairment
Social Anxiety disorder
Fear of scrutiny by others in social situations
Specific Phobia
Fear of specific object or situation
Diagnostic uncertainty
OTHER Specified
Gives REASON why don’t meet criteria
UNspecified
Reason NOT GIVEN why didn’t meet criteria
What is a negative Sx?
RESTRICTION in range/intensity of emotions/other functions
Negative Sx
Blunted emotional expression Anhedonia Asociality Alogia Avolition
Delusions
False beliefs despite contrary evidence
Types of delusions
Persecutory** Referential** Bizarre** ***most common in schizophrenia Erotomanic Grandiose Jealous Somatic Mixed Unspecified
Disorganized thinking
Loose, incoherent, off-track, one topics to another
Grossly disorganized or abnormal motor behavior
Unpredictable agitation
Disheveled appearance
Inappropriate sexual behavior
Catatonia
Delusional Disorder
One or more delusions for one month or more
Schizophrenia Dx criteria
2+ active phase Sx for at least one month
1 Sx must be delusions, hallucinations, or disorganized speech
Continuous signs for 6 mos.
Significant impairment of functioning
Schizophrenia prevalence rates
.3-.7%
Slightly less for females
Schizophrenia age of onset
Males: early - mid 20s
Females: late 20s
Schizophrenia concordance rates
Bio sibs 10%
Fraternal twins 17%
Identical twins 48%
2 parents 46%
Dopamine hypothesis
Excessive dopamine, over sensitive receptors
Brain abnormalities in schizophrenia
Enlarged ventricles
Smaller hippo, amygdala, globus pallidus
Hypofrontality (negative Sx, poor cognition)
Traditional vs atypical antipsychotics
Traditional: reduce + Sx, but risk tar dive dyskinesia
(Haloperidol, fluphenazine)
Atypical: reduce + and - Sx
(Clozapine, risperidone)
Schizophreniform disorder
1-6 mos
Social/occupational impairment not necessary
2/3 go on to full Schizophrenia or schizoaffective Dx
Brief Psychotic disorder
1 DAY - 1 mo. (Often response to overwhelming stressor) 1 or more Sx: Delusions** Hallucinations** Disorganized speech** Motor Sx or catatonic
Schizoaffective disorder
Concurrent schizophrenia Sx + major depressive or manic Sx
At least 2 week period w/o mood Sx
BP I
At least 1 manic episode
Marked impairment req hospitalization or includes psychotic feature
MAY include 1 or more hypomanic or major depressive episodes
BP II
REQUIRES at least one hypomanic + one major depressive
What’s the difference between mania and hypomania?
Mania: psychosis and/or requires hospital; marked impairment
Hypomania: doesn’t cause impairment or req hospital
Rx for BP
Lithium 60-90% effective for classic BP I (discrete high/low episodes)
Anti seizure Rxs (carbamazepine or divalproex sodium) effective for rapid cycling or dysphoric mania
Antipsychotics for acute mania (olanzapine, risperidone)
Cyclothymic disorder
Numerous periods of hypomanic and depressive episodes
Don’t meet full criteria
Not Sx-free for more than 2 mos at a time
Duration: 2 yrs adults, 1 yr child/adolescent
Major Depressive Disorder
At least 5 Sx for at least 2 weeks: **depressed mood **loss interest or pleasure in most/all activities (**must have one) Sig weight loss Weight gain, or up/down appetite Insomnia/hypersomnia Psychomotor agitation/retardation Fatigue/loss of energy Worthlessness/excessive guilt Inability to think or concentrate Recurrent thoughts of death Suicide ideation or attempts
MDD comorbidity with anxiety
60%
MDD prevalence
7% in USA
Adolescent females 1.5-3 times higher than males
18-29 yo 3xs higher than over 60
MDD peak age of onset
Mid 20s
Disruptive Mood Disregulation Disorder
- -severe recurrent outbursts (verbal/behaviorally)
- -chronic persistent angry mood between outbursts
- -Sx 12 mos, 2 of 3 settings
- -inconsistent with developmental level
- -Dx: 6-18 yo (onset before 10)
Associated features of MDD
EEG abnormalities in sleep - 40-60%
Sleep continuity disturbances, reduced Stage 3/4 (slow wave)
Reduced REM latency (early REM onset)
Increased REM duration
Pseudodementia vs neurocognitive disorder
Pseudo–> abrupt onset, patient concerned with impairments
Neurocog–> gradual onset, patient denies/unaware
MDD prevalence
.50 monozygotic twins
.20 dizygotic twins
1.5-3 xs more common in 1st degree relatives
Catecholemine hypothesis
MDD = deficit in norepinephrine
Indolamine hypothesis
MDD = deficit in serotonin
Consequence of untreated MDD
Increased cortisol = atrophy of neurons in hippo
Lewinsohn behavioral theory of depression
Operant conditioning – low rate of response-contingent reinforcement
Seligman Learned Helplessness
Attributes events to internal, stable, global factors
Updated version: HOPELESSNESS is proximal and sufficient cause
Rehm Self-Control Model
cannot self-monitor, self evaluate, self reinforce properly
Beck Cognitive theory (depressive triad)
Self, world, future
MDD differential Dxs
psychotic Sx –> if exclusively during MDD episode (MDD w/psychotic features)
Psychosocial stressor –> Adjustment Disorder w/depressed mood (MDD criteria not met)
normal mood, feelings of loss/emptiness, decreases over days/weeks–> Uncomplicated Bereavement
TCAs (imipramine)
Most effective: Classic MDD w/vegetative Sx, worse in am, acute onset, moderate Sx severity
SSRIs
Mod to severe MDD
Low side effects, low risk of fatal OD compared to TCAs
MAOIs
Atypical Sx of MDD
SNRIs
Comparable to TCAs/SSRIs in effectiveness Differ in side effects Venlafaxine (Effexor) Desvenlafaxine (Pristiq) Duloxetine (Cymbalta)
Side effects of ECT
Temporary ant and retro amnesia
Confusion
Disorientation
(Reduced only of unilateral Tx: right, non-dominant side)
Persistent Depressive Disorder
Dysthymia
Depressed mood most days (2 yrs adults; 1yr kids) Not Sx-free more than 2 mos At least two Sx: **Poor appetite/overeating **insomnia/hypersomnia **low energy/fatigue low self esteem **Poor concentration/diff making decisions Hopelessness (**same as MDD)
Tx for Persistent Depressive Disorder
CBT or IPT + SSRIs
Premenstrual Dysphoric Disorder
Most cycles, at least 5 Sx week before period
Sx improve few days after onset
Absent or min Sx post-period
Must have one: affect lability/irritability/anger, depressed mood or self-dep thoughts, anxiety/tension
At least one: decreased interest in usual activities, impaired concentration, lethargy, change in appetite, insomnia/hypersomnia, overwhelm/out of control, physical Sx
Suicide risk factors
Age: 45-54 highest (both sexes combined) 75 and up (males) Gender: 4xs more males complete, 2-3 xs more females attempt Race: highest for whites (except NAmer 15-34 2xs higher) Divorced, separated, widowed - highest Single Married 60-80% commit tried before 80% give definite warning
Life stressors Assoc with risk of suicide
Failed at work or school
Rejected by loved one
Living alone
Absence of social support
Perfectionism and suicide risk
Socially-prescribed==> increased depression, low suicide risk
Self-oriented==> high suicide risk only with increased life stress
Suicide interventions
*Hospitalization: attempt or imminent risk
*Outpatient crisis unit: mod risk (intention, lack of means)
(Goals: decrease social isolation, removing lethal means, expressing anger other ways, red anxiety/sleep problems, focusing on ambivalence re: making attempt until crisis has passed)
*Outpatient therapy: follow up to hospital or outpt clinic, or if low risk
(CBT, IPT, DVT, problem-solving therapy)
How does anxiety differ from depression?
both have neg affect, but anxiety has higher positive affect and autonomic arousal
Anxiety vs depression Sx
"Pure" Anxiety Sx: Apprehension Tension Trembling Excessive worry Nightmares
"Pure"depression Sx: Poor mood Anhedonia Loss of interest in activities Suicide ideation Loss of libido
Overlapping Sx: Poor concentration/memory Irritability Fatigue Insomnia Hopelessness
Separation Anxiety
Child: 4 weeks
Adult: 6 months
Causes of school refusal (by age)
5-7 yo – beginning school
10-11 yo – change of schools; social phobia
14-16 yo – social phobia; depression; POOR prognosis
Tx for Separation Anxiety
Systematic desensitization
Cognitive approaches – for older kids/adolescents
Specific Phobia
Intense fear/anxiety re: SPECIFIC object or situation
Typically lasts 6 mos or more
Specifier for Specific Phobia
Animal Natural environment Blood-injection-injury Situational Other
Etiology of Specific Phobia
Biological : abnormal serotonin, norepinephrine, GABA)