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Prudent use of AB - exam > AB table - everything > Flashcards

AB table - everything Flashcards

1
Q

Beta lactam antibiotic groups:

A 
Penicillins
Beta-lactamase inhibitors
Cephalosporins
carbapenems
Monobactams
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2
Q

Penicillins are splt into 4 groups based on their spectrum, what are the groups?

A
  1. Narrow spectrum penicillins
  2. Penicillinase stable penicillins
  3. Broad spectrum penicillins
  4. Penicillins acting against pseudomonas spp.
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3
Q
  1. Narrow spectrum penicillins : substances
A

Benzylpenicillin-Na,K
Benzylpenicillins-procaine
benzylpenicillin-benzathine
Phenoxymethyl-penicillin

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4
Q
  1. Penicillinase stable penicillins : substances
A

Oxacillin
cloxacillin
dicloxacillin
flucloxacillin

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5
Q
  1. Broad spectrum penicillins : substances
A

amoxicillin

ampicillin

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6
Q
  1. Penicillins acting against pseudomonas spp. : substances
A

ticarcillin

piperacillin

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7
Q

What is penicillins mode of action?

A

Time dependent bactericidal

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8
Q

what is penicillins mechanism of action?

A

inhibition of cell wall synthesis

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9
Q

Beta-lactamase inhibitors: substances:

A

clavulanic acid
sulbactam
tazobactam

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10
Q

Beta-lactamase inhibitors mode of action:

A

Time dependent bactericidal

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11
Q

Beta-lactamase inhibitors mechanism of action:

A

inhibition of cell wall synthesis

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12
Q

All the Beta lactam antibiotic groups have the same mode of action :

A

Time dependent bactericidal

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13
Q

All the Beta lactam antibiotic groups have the same mechanism of action :

A

inhibition of cell wall synthesis

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14
Q

Cephalosporins are split into 4 groups:

A

1-4th generations

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15
Q

1st generation Cephalosporins

A

cephazoline
cephapirin
cefadroxil
cephalexin

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16
Q

2nd generation Cephalosporins

A

cefuroxime

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17
Q

3rd generation Cephalosporins

A 
ceftiofur
cefovecin
ceftriaxone
cefotaxime
ceftazidime
cefoperazone
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18
Q

4th generation Cephalosporins

A

cefquinome

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19
Q

Cephalosporins mode and mechanism of action:

A

Time dependent bactericidal and inhibition of the cell wall synthesis

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20
Q

Carbapenems substances:

A

imipenem

meropenem

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21
Q

Carbapenems mode and mechanism of action:

A

Time dependent bactericidal and inhibition of the cell wall synthesis

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22
Q

monobactams substances:

A

aztreonam

tigemonam

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23
Q

monobactams mode and mechanism of action:

A

Time dependent bactericidal and inhibition of the cell wall synthesis

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24
Q

Give the concentration dependent bactericidal drug groups:

A
  1. Aminoglycosides
  2. Polypeptide AB¨
  3. Fluoroquinolones
  4. Nitroimidazoles
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25
Aminoglycosides - substances:
``` Streptomycin neomycin paromomicin kanamycin gentamicin tobramycin amikacin apramycin spectinomycin ```
26
One of the aminoglycosides are bacteriostatic, which one?
Spectinomycin
27
what is the mechanism of action of aminoglycosides?
inhibition of protein synthesis (30S subunit), mistranslation
28
Tetracyclines are split into two groups:
1. Short acting | 2. Lang acting
29
what are the short acting tetracyclines?
chlortetrcycline oxytetracycline tetracycline
30
what are the long acting tetracyclines?
doxycycline | minocycline
31
Tetracyclines - what is the mode of action ?
bacteriostatic
32
Tetracyclines - what is the mechanism of action ?
inhibition of protein synthesis (30S subunit)
33
Which are the bacteriostatic AB?
``` Spectinomycin (aminoglycoside) Tetracyclines Macrolides Lincosamides Pleuromutilins Phenicols Fusidic acid ```
34
Macrolides - substances:
``` erythromycin azithromycin clarithromycin spiramycin tylosin tylvalosin tilmicosin tulathromycin gamithromycin tildipirosin ```
35
Macrolides - Mechanism of action:
inhibition of protein synthesis (50S subunit)
36
Macrolides - Mode of action:
Bacteriostatic
37
Lincosamides - substances:
lincomycin | clindamycin
38
Lincosamides - Mode of action
Bacteriostatic
39
Lincosamides - Mechanism of action
inhibition of protein synthesis (50S subunit)
40
Pleuromutilins - substances
tiamulin | valnemulin
41
Pleuromutilins - mode
Bacteriostatic
42
Pleuromutilins - mechanism
inhibition of protein synthesis (50S subunit)
43
Phenicols - substances
florfenicol thiamphenicol chlorampenicol
44
Phenicols - mode
Bacteriostatic
45
Phenicols - mechanism
inhibition of protein synthesis (50S subunit)
46
There are two groups of peptide AB:
1. Polypeptide AB | 2. Glycopeptide AB
47
1. Polypeptide AB - substances
bacitracin polymyxin B polymyxin E = colistin
48
2.Glycopeptide AB - substances
vancomycin | teicoplanin
49
1. Polypeptide AB - mode
concentration dependent bactericidal
50
1. Polypeptide AB - mechanism
they act like a cationic detergent
51
2.Glycopeptide AB - mechanism
inhibition of cell wall synthesis
52
2.Glycopeptide AB - mode
time dependent bactericidal
53
Rifamycines - substance
rifampicin
54
rifampicin . mechanism
inhibit bacterial DNA-dependent RNA polymerase
55
rifampicin - mode
time dependent bactericidal
56
Give the bactericidal AB groups: (not the dependent)
Pseudomonic acid Phosphonic acid derivates Nitrofurans
57
Pseudomonic acid - substance
Mupiocin
58
Pseudomonic acid - mode
bactericidal
59
Pseudomonic acid - mechanism
inhibition of cell wall synthesis
60
Phosphonic acid derivates- substance
fosfomycin
61
Phosphonic acid derivates - mode
bactericidal
62
Phosphonic acid derivates- mechanism
inhibition of cell wall synthesis
63
Fusidic acid - substance
fusidic acid
64
Fusidic acid - mode
bacteriostatic
65
Fusidic acid - mechanism
inhibition of protein synthesis
66
Sulphonamides - substances
``` sulfadimidine sulfadiazine sulfachlorpyridazine sulfachlorpyrazine sulfamethoxasole sulfadoxine sulfaquinoxaline sulfasalazine ```
67
Sulphonamides - mode
separately bacteriostatic and combination time dependent bactericidal
68
Sulphonamides - mechanism
inhibition of folic acid synthesis
69
Diaminopyrimides - substances
trimethoprim | baquiloprim
70
Diaminopyrimides - mode
separately bacteriostatic and combination time dependent bactericidal
71
Diaminopyrimides - mechanism
inhibition of folic acid synthesis
72
Fluoroquinolones - 1st generation substances
nalidixic acid
73
Fluoroquinolones - 2nd generation substances
``` flumequine norfloxacin ciprofloxacin enrofloxacin danofloxacin difloxacin marbofloxacin ```
74
Fluoroquinolones - 3rd generation substances
levofloxacin | sparfloxacin
75
Fluoroquinolones - 4th generation substances
pradofloxacin | moxifloxacin
76
Fluoroquinolones - mode
concentration dependent bactericidal
77
Fluoroquinolones - mechanism
inhibition of DNA synthesis
78
Nitrofurans - substances
nitrofurantoin | furazolidone
79
Nitrofurans - mode
bactericidal
80
Nitrofurans - mechanism
destroy the DNA of bacteria
81
Nitroimidazoles- substances
metronidazole ronidazole tinidazole
82
Nitroimidazoles- mode
concentration dependent bactericidal
83
Nitroimidazoles - mechanism
destroy the DNA of bacteria

Prudent use of AB - exam (6 decks)

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