AB table - everything Flashcards
Beta lactam antibiotic groups:
Penicillins Beta-lactamase inhibitors Cephalosporins carbapenems Monobactams
Penicillins are splt into 4 groups based on their spectrum, what are the groups?
- Narrow spectrum penicillins
- Penicillinase stable penicillins
- Broad spectrum penicillins
- Penicillins acting against pseudomonas spp.
- Narrow spectrum penicillins : substances
Benzylpenicillin-Na,K
Benzylpenicillins-procaine
benzylpenicillin-benzathine
Phenoxymethyl-penicillin
- Penicillinase stable penicillins : substances
Oxacillin
cloxacillin
dicloxacillin
flucloxacillin
- Broad spectrum penicillins : substances
amoxicillin
ampicillin
- Penicillins acting against pseudomonas spp. : substances
ticarcillin
piperacillin
What is penicillins mode of action?
Time dependent bactericidal
what is penicillins mechanism of action?
inhibition of cell wall synthesis
Beta-lactamase inhibitors: substances:
clavulanic acid
sulbactam
tazobactam
Beta-lactamase inhibitors mode of action:
Time dependent bactericidal
Beta-lactamase inhibitors mechanism of action:
inhibition of cell wall synthesis
All the Beta lactam antibiotic groups have the same mode of action :
Time dependent bactericidal
All the Beta lactam antibiotic groups have the same mechanism of action :
inhibition of cell wall synthesis
Cephalosporins are split into 4 groups:
1-4th generations
1st generation Cephalosporins
cephazoline
cephapirin
cefadroxil
cephalexin
2nd generation Cephalosporins
cefuroxime
3rd generation Cephalosporins
ceftiofur cefovecin ceftriaxone cefotaxime ceftazidime cefoperazone
4th generation Cephalosporins
cefquinome
Cephalosporins mode and mechanism of action:
Time dependent bactericidal and inhibition of the cell wall synthesis
Carbapenems substances:
imipenem
meropenem
Carbapenems mode and mechanism of action:
Time dependent bactericidal and inhibition of the cell wall synthesis
monobactams substances:
aztreonam
tigemonam
monobactams mode and mechanism of action:
Time dependent bactericidal and inhibition of the cell wall synthesis
Give the concentration dependent bactericidal drug groups:
- Aminoglycosides
- Polypeptide AB¨
- Fluoroquinolones
- Nitroimidazoles
Aminoglycosides - substances:
Streptomycin neomycin paromomicin kanamycin gentamicin tobramycin amikacin apramycin spectinomycin
One of the aminoglycosides are bacteriostatic, which one?
Spectinomycin
what is the mechanism of action of aminoglycosides?
inhibition of protein synthesis (30S subunit), mistranslation
Tetracyclines are split into two groups:
- Short acting
2. Lang acting
what are the short acting tetracyclines?
chlortetrcycline
oxytetracycline
tetracycline
what are the long acting tetracyclines?
doxycycline
minocycline
Tetracyclines - what is the mode of action ?
bacteriostatic
Tetracyclines - what is the mechanism of action ?
inhibition of protein synthesis (30S subunit)
Which are the bacteriostatic AB?
Spectinomycin (aminoglycoside) Tetracyclines Macrolides Lincosamides Pleuromutilins Phenicols Fusidic acid