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Prudent use of AB - exam > AB table - everything > Flashcards

AB table - everything Flashcards

1
Q

Beta lactam antibiotic groups:

A 
Penicillins
Beta-lactamase inhibitors
Cephalosporins
carbapenems
Monobactams
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2
Q

Penicillins are splt into 4 groups based on their spectrum, what are the groups?

A
  1. Narrow spectrum penicillins
  2. Penicillinase stable penicillins
  3. Broad spectrum penicillins
  4. Penicillins acting against pseudomonas spp.
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3
Q
  1. Narrow spectrum penicillins : substances
A

Benzylpenicillin-Na,K
Benzylpenicillins-procaine
benzylpenicillin-benzathine
Phenoxymethyl-penicillin

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4
Q
  1. Penicillinase stable penicillins : substances
A

Oxacillin
cloxacillin
dicloxacillin
flucloxacillin

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5
Q
  1. Broad spectrum penicillins : substances
A

amoxicillin

ampicillin

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6
Q
  1. Penicillins acting against pseudomonas spp. : substances
A

ticarcillin

piperacillin

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7
Q

What is penicillins mode of action?

A

Time dependent bactericidal

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8
Q

what is penicillins mechanism of action?

A

inhibition of cell wall synthesis

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9
Q

Beta-lactamase inhibitors: substances:

A

clavulanic acid
sulbactam
tazobactam

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10
Q

Beta-lactamase inhibitors mode of action:

A

Time dependent bactericidal

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11
Q

Beta-lactamase inhibitors mechanism of action:

A

inhibition of cell wall synthesis

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12
Q

All the Beta lactam antibiotic groups have the same mode of action :

A

Time dependent bactericidal

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13
Q

All the Beta lactam antibiotic groups have the same mechanism of action :

A

inhibition of cell wall synthesis

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14
Q

Cephalosporins are split into 4 groups:

A

1-4th generations

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15
Q

1st generation Cephalosporins

A

cephazoline
cephapirin
cefadroxil
cephalexin

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16
Q

2nd generation Cephalosporins

A

cefuroxime

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17
Q

3rd generation Cephalosporins

A 
ceftiofur
cefovecin
ceftriaxone
cefotaxime
ceftazidime
cefoperazone
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18
Q

4th generation Cephalosporins

A

cefquinome

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19
Q

Cephalosporins mode and mechanism of action:

A

Time dependent bactericidal and inhibition of the cell wall synthesis

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20
Q

Carbapenems substances:

A

imipenem

meropenem

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21
Q

Carbapenems mode and mechanism of action:

A

Time dependent bactericidal and inhibition of the cell wall synthesis

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22
Q

monobactams substances:

A

aztreonam

tigemonam

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23
Q

monobactams mode and mechanism of action:

A

Time dependent bactericidal and inhibition of the cell wall synthesis

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24
Q

Give the concentration dependent bactericidal drug groups:

A
  1. Aminoglycosides
  2. Polypeptide AB¨
  3. Fluoroquinolones
  4. Nitroimidazoles
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25
Q

Aminoglycosides - substances:

A 
Streptomycin
neomycin
paromomicin
kanamycin
gentamicin
tobramycin
amikacin
apramycin
spectinomycin
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26
Q

One of the aminoglycosides are bacteriostatic, which one?

A

Spectinomycin

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27
Q

what is the mechanism of action of aminoglycosides?

A

inhibition of protein synthesis (30S subunit), mistranslation

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28
Q

Tetracyclines are split into two groups:

A
  1. Short acting

2. Lang acting

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29
Q

what are the short acting tetracyclines?

A

chlortetrcycline
oxytetracycline
tetracycline

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30
Q

what are the long acting tetracyclines?

A

doxycycline

minocycline

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31
Q

Tetracyclines - what is the mode of action ?

A

bacteriostatic

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32
Q

Tetracyclines - what is the mechanism of action ?

A

inhibition of protein synthesis (30S subunit)

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33
Q

Which are the bacteriostatic AB?

A 
Spectinomycin (aminoglycoside)
Tetracyclines 
Macrolides
Lincosamides
Pleuromutilins
Phenicols
Fusidic acid
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34
Q

Macrolides - substances:

A 
erythromycin
azithromycin
clarithromycin
spiramycin
tylosin
tylvalosin
tilmicosin
tulathromycin
gamithromycin
tildipirosin
35
Q

Macrolides - Mechanism of action:

A

inhibition of protein synthesis (50S subunit)

36
Q

Macrolides - Mode of action:

A

Bacteriostatic

37
Q

Lincosamides - substances:

A

lincomycin

clindamycin

38
Q

Lincosamides - Mode of action

A

Bacteriostatic

39
Q

Lincosamides - Mechanism of action

A

inhibition of protein synthesis (50S subunit)

40
Q

Pleuromutilins - substances

A

tiamulin

valnemulin

41
Q

Pleuromutilins - mode

A

Bacteriostatic

42
Q

Pleuromutilins - mechanism

A

inhibition of protein synthesis (50S subunit)

43
Q

Phenicols - substances

A

florfenicol
thiamphenicol
chlorampenicol

44
Q

Phenicols - mode

A

Bacteriostatic

45
Q

Phenicols - mechanism

A

inhibition of protein synthesis (50S subunit)

46
Q

There are two groups of peptide AB:

A
  1. Polypeptide AB

2. Glycopeptide AB

47
Q
  1. Polypeptide AB - substances
A

bacitracin
polymyxin B
polymyxin E = colistin

48
Q

2.Glycopeptide AB - substances

A

vancomycin

teicoplanin

49
Q
  1. Polypeptide AB - mode
A

concentration dependent bactericidal

50
Q
  1. Polypeptide AB - mechanism
A

they act like a cationic detergent

51
Q

2.Glycopeptide AB - mechanism

A

inhibition of cell wall synthesis

52
Q

2.Glycopeptide AB - mode

A

time dependent bactericidal

53
Q

Rifamycines - substance

A

rifampicin

54
Q

rifampicin . mechanism

A

inhibit bacterial DNA-dependent RNA polymerase

55
Q

rifampicin - mode

A

time dependent bactericidal

56
Q

Give the bactericidal AB groups: (not the dependent)

A

Pseudomonic acid
Phosphonic acid derivates
Nitrofurans

57
Q

Pseudomonic acid - substance

58
Q

Pseudomonic acid - mode

A

bactericidal

59
Q

Pseudomonic acid - mechanism

A

inhibition of cell wall synthesis

60
Q

Phosphonic acid derivates- substance

A

fosfomycin

61
Q

Phosphonic acid derivates - mode

A

bactericidal

62
Q

Phosphonic acid derivates- mechanism

A

inhibition of cell wall synthesis

63
Q

Fusidic acid - substance

A

fusidic acid

64
Q

Fusidic acid - mode

A

bacteriostatic

65
Q

Fusidic acid - mechanism

A

inhibition of protein synthesis

66
Q

Sulphonamides - substances

A 
sulfadimidine
sulfadiazine
sulfachlorpyridazine
sulfachlorpyrazine
sulfamethoxasole
sulfadoxine
sulfaquinoxaline
sulfasalazine
67
Q

Sulphonamides - mode

A

separately bacteriostatic and combination time dependent bactericidal

68
Q

Sulphonamides - mechanism

A

inhibition of folic acid synthesis

69
Q

Diaminopyrimides - substances

A

trimethoprim

baquiloprim

70
Q

Diaminopyrimides - mode

A

separately bacteriostatic and combination time dependent bactericidal

71
Q

Diaminopyrimides - mechanism

A

inhibition of folic acid synthesis

72
Q

Fluoroquinolones - 1st generation substances

A

nalidixic acid

73
Q

Fluoroquinolones - 2nd generation substances

A 
flumequine
norfloxacin
ciprofloxacin
enrofloxacin
danofloxacin
difloxacin
marbofloxacin
74
Q

Fluoroquinolones - 3rd generation substances

A

levofloxacin

sparfloxacin

75
Q

Fluoroquinolones - 4th generation substances

A

pradofloxacin

moxifloxacin

76
Q

Fluoroquinolones - mode

A

concentration dependent bactericidal

77
Q

Fluoroquinolones - mechanism

A

inhibition of DNA synthesis

78
Q

Nitrofurans - substances

A

nitrofurantoin

furazolidone

79
Q

Nitrofurans - mode

A

bactericidal

80
Q

Nitrofurans - mechanism

A

destroy the DNA of bacteria

81
Q

Nitroimidazoles- substances

A

metronidazole
ronidazole
tinidazole

82
Q

Nitroimidazoles- mode

A

concentration dependent bactericidal

83
Q

Nitroimidazoles - mechanism

A

destroy the DNA of bacteria

Prudent use of AB - exam (6 decks)

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