A.13

Question 1

α-receptor antagonist

Answer 1

Prazosin,
Doxazosin,
Tamsuloszin,
Urapidil,
Carvedilol,
Phentolamine

Question 2

Prazosin

Answer 2

MOA: α1-selective antagonist;
ROA: p.o;
Effect: Relax muscle of prostate+bladder allowing urine to flow easily;
IND: HTN, BPH, Raynaud syndrome, cardiac insufficiency;
SEs: Orthostatic hypotension

Question 3

Doxazosin

Answer 3

MOA: α1-selective antagonist;
ROA: p.o ;
Effect: Relax muscle of prostate+bladder allowing urine to flow easily;
IND: HTN, BPH;
SEs: Orthostatic hypotension

Question 4

Tamsulosin

Answer 4

MOA: α1-selective antagonist;
ROA: p.o ;
Effect: Relax muscle of prostate+bladder allowing urine to flow easily

Question 5

Carvedilol

Answer 5

MOA: α1-selective antagonist, β-antagonist;
ROA: p.o, i.v;
IND: HTN, CHF, chronic stable angina;
Extra: Antioxidant properties (↓production of free radicals)

Question 6

Phentolamine

Answer 6

MOA: non-selective α-antagonist (reversible competitive);
ROA: parentral;
Effect: vasodilation, ↓BP;
IND: Pheochromocytoma (diagnosis+treatment), antidote in case of acute HTN due to α-agonist overdose (e.g. cocaine, amphetamines);
SEs: Orthostatic hypotension w/reflex tachycardia, nasal congestion, headach