A 6 Flashcards
What are the two phagocyte inducing molecules called that all phagocytes recognize?
Fc, and C3b (complement)
What does IFN gamma do to a macrophage?
Activates it so that it can kill bacteria such as tuberculosis.
What receptors do monocytes require for microbial sensing and differentiation?
TLR’s and CD14
What receptors do monocytes require for microbial sensing and differentiation?
TLR’s and CD14
What are the receptors for C3b and iC3b on phagocytes called?
C3b receptor = CR1
IC3b receptor = CR3
What would happen if the bacteria being engulfed was not completely covered by IgG or C3b tags?
The bacteria would not be entirely engulfed and digestive compounds could leak out causing damage to the surroundings.
Which 2 molecules activate macrophages that have an intracellular bacterium?
TNF alpha
IFN gamma
Which cells are an essential link between innate and adaptive immunity?
Dendritic cells
What is CCR2?
A receptor on monocytes that allow them to enter the tissues (it binds the CCL2 ligand)
Which receptors allow macrophages/ monocytes to leave the tissues to go to lymph nodes to gain Dendritic cell-like properties?
CCR7 and CCR8
what initiates the respiratory burst?
NADPH oxidase
Hydrogen peroxide becomes bleach (HOCL) through the enzyme called?
MPO (myeloperoxidase)
NADPH and 02 is converted to ___________ by NADPH oxidase, which also spontaneously breaks to make Hydrogen peroxide.
Superoxide (radical)
where do you find NADPH oxidase?
facing inward in the phagolysosome. Note: the activation was controlled because it had to be assembled from parts found in different areas of the cell.
what does IFN gamma do in macrophages?
activates it with more NADPH oxidase activity and enhanced lysosomal/phagocyte fusion.
