A 2 Flashcards
Wright stain does what?
-Stains immune cells so we can see the different histologies
What cells are derived from a common myeloid progenitor cell?
- Megakaryoctye
- RBC
- Myeloblast (makes WBC’s)
- Mast cell
What cells are derived from common lymphoid progenitor?
- Natural Killers
- Lymphocytes
Spontaneous Erythrocyte Sedimentation Rate (in a test tube) is faster under what conditions?
Inflammation
What allowed mono-clonal antibody technology, immunotypes, and immune geno-expression by PCR?
-Discovery of CD’s (Cluster of differentiation) molecules (realize they are important to these technologies if a test question on technologies comes up)
CD 34 is present on which cells?
Stem cells
CD 45 is present on which cells?
Immune cells (all that we know of)
Defensins & lipid mediators serve what general function in the immune system?
-Immediate encounter with foreign material
CD 3 is present on which cells?
-T lymphocytes
Note: My tutors told me to be able to calculate a doubling time from a graph
So… go look at the graph and make sure you can do that.
What function do the epiglottis, GE junction, and UP junction serve in the immune system?
-Physical barriers
Where are chemical lysozyme barriers as well as Anti-Microbial Peptides generally found?
-Skin, tears, saliva, milk, PMN granules.
What is the function of lysozyme?
Degrade peptidoglycan in bacterial cell walls
What is the function of Anti-Microbial Peptides?
Punch holes in membranes (similar to MAC from complement)
Which tight junctions in the gut are leaky and which are tight?
-IL 17=leaky
-IL 10=tight
(Both are influenced by bacteria, and have a role in Crohns disease and UC)
T/F the gut microbiome can be anti-inflammatory?
True
What is HSP 25? (for purpose of this class)
An immune system protein in the colon that is not expressed unless bacteria are present
Epidemiology X Microbiology Divided by WHAT = Risk of infection?
Anatomy X Immunology
ID 50 is what?
Number bacteria sufficient to infect 50% of people
What is the critical step in initiating immune response?
-Recognition
What are commensal bacteria?
Symbiotic bacteria such as in the gut
What is an interferon?
A chemical signal released by an invaded cell that warns and prepares neighboring cells of an invader.
Which two TLR ‘s signal for interferon (IFN) release? (For our purposes)
TLR 3 and TLR 7. ( why? Because these sense RNA SS and DS which are indicative of bacteria or virus)
