A 4 Bone And Cartilage Flashcards
Hyaline (w/ Type 2 collagen) locations
Articulations, temporary skeleton, ventral ends of ribs, larynx, trachea, bronchi
Somatocedin C
Cartilage growth factor (from liver)
Elastic Cartilage locations (w/ Type 2 collagen)
Where flexibility of required; auricle of ear; external auditory meatus, auditory tube, epiglottis, parts of larynx
Fibrous cartilage locations (w/ Type 1 collagen)
Intervertebral discs, pubic symphysis, and ligaments and tendons
The inorganic part of Bone Matrix Consists of:
- Type 1 collagen
- gylcoproteins
- Hydroxyapatite
- CaPo4
- Other minerals like carbonate, potassium, Mg, Na, citrate
Bone Calcium Increases By:
- Vit D
- Calcitonin (inhibit osteoclast)
- Androgens
- Growth Hormone (increase bone deposition/density)
- Estrogens (decrease turnover)
Bone Decreases by:
- Parathyroid Hormone (Ca+ from bone -> blood)
- Thyroxine (stimulates osteoclasts)
Bone % Composition
- Mineral is 75% of bone TOTAL weight
- Collagen about 90% DRY weight of bone organic component
Trabeculated Bone measurements
- Trabeculae 0.2 mm
- Plate 1 mm
What do proteoglycans bind?
Fluids, cations, and growth factors
What is the function of chondronectin?
It binds a Chondrocyte to collagen
What is wolfs law?
Use and disuse determines bone density
Hydroxyproline is found where?
With collagen in the ECM. (don’t confuse w/ keratin)
Where do bone minerals nuclear? (Deposit)
Collagen and secreted vesicles
What gives bone it’s hardness?
Hydroxyapatite
Which type of cartilage is acidophilic?
Fibrous cartilage. This is because it has an overall + charge which attracts the acidic ( - )charged dye.
Which type of cartilage is basophilic?
Type 2 hyaline cartilage. (Opposite to fibrous)
What % of a bones dry weight is from collagen?
75%
