A 4 Bone And Cartilage Flashcards
Hyaline (w/ Type 2 collagen) locations
Articulations, temporary skeleton, ventral ends of ribs, larynx, trachea, bronchi
Somatocedin C
Cartilage growth factor (from liver)
Elastic Cartilage locations (w/ Type 2 collagen)
Where flexibility of required; auricle of ear; external auditory meatus, auditory tube, epiglottis, parts of larynx
Fibrous cartilage locations (w/ Type 1 collagen)
Intervertebral discs, pubic symphysis, and ligaments and tendons
The inorganic part of Bone Matrix Consists of:
- Type 1 collagen
- gylcoproteins
- Hydroxyapatite
- CaPo4
- Other minerals like carbonate, potassium, Mg, Na, citrate
Bone Calcium Increases By:
- Vit D
- Calcitonin (inhibit osteoclast)
- Androgens
- Growth Hormone (increase bone deposition/density)
- Estrogens (decrease turnover)
Bone Decreases by:
- Parathyroid Hormone (Ca+ from bone -> blood)
- Thyroxine (stimulates osteoclasts)
Bone % Composition
- Mineral is 75% of bone TOTAL weight
- Collagen about 90% DRY weight of bone organic component
Trabeculated Bone measurements
- Trabeculae 0.2 mm
- Plate 1 mm
What do proteoglycans bind?
Fluids, cations, and growth factors
What is the function of chondronectin?
It binds a Chondrocyte to collagen
What is wolfs law?
Use and disuse determines bone density
Hydroxyproline is found where?
With collagen in the ECM. (don’t confuse w/ keratin)
Where do bone minerals nuclear? (Deposit)
Collagen and secreted vesicles
What gives bone it’s hardness?
Hydroxyapatite
