9.1 Blood Component PReparation Flashcards by Miguel Acosta | Brainscape

Q

Use of Transfusion therapy:

Inadequate Oxygen carrying capacity because of _________________

Insufficient coagulation proteins or platelets to provide adequate hemostasis

A

Anemia or Blood loss

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Q

2 types of Blood Collection:

Collection of Blood in a sterile container

A

Close system

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Q

2 types of Blood Collection:

Collection or exposure to air through an open port that would shorten the expiration because of potential bacterial contamination

A

Open system

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Q

What is the expiration for open system RBC?

A

24 hours

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Q

What is the expiration for open-system platelets

A

4 hours

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Q

Platelet concentrate is stored at what temp?

A

Room temp

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Q

The Goal of RBC Preservation is to provide viable and functional blood components for patients requiring blood transfusion

T or F

A

T

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Q

FDA requires an average of ____ hour post transfusion for RBC preservation which allows RBC survival of more than ____%

A

24, 75

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Q

For RBC Preservative Anticoagulant:

What is the Storage time for:

Acid-Citate-Dextrose (ACD)

A

21 days

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Q

For RBC Preservative Anticoagulant:

What is the Storage time for:

Citrate-Phosphat-Dextrose (CPD)

A

21 Days

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Q

For RBC Preservative Anticoagulant:

What is the Storage time for:

Citrate-Phosphate-Double-Dextrose (CP2D)

A

21

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Q

For RBC Preservative Anticoagulant:

What is the Storage time for:

Citrate-Phosphate-Adenine (CPDA-1 and 2)

A

35

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Q

RBC preservative that Allows RBC to store for 10 years

A

Frozen RBC

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Q

Benefits of RBC Additive Solutions:

Extends the Shelf-life of RBC to __ days by adding nutrients

A

42

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Q

Benefits of RBC Additive Solutions:

Produces an RBC concentrate of ___________ viscosity that is easier to infuse

A

Lower

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Q

Benefits of RBC Additive Solutions:

Allows harvesting of more plasma and platelets from the unit

T or F

A

T

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Q

What do you call the fluid inside the mother and daughter bags

A

Anticoagulant preservative

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Q

Additive solution is usually found in the ______ satellite bag

A

Last

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Q

Additive solution is added AFTER the removal of Plasma

T or F

A

T

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Q

Additive solutions:

Adsol (AS-_)
Nutricel (AS-__)
Optisol (AS-_)
SOLX (AS-_)

A

1,3,5,7

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Q

Additive solution allows to extend life of RBC or blood up to?

A

42 days

Q

The additive solution must be added within ___ hours of WBC

A

72

Q

When Adding Additive solution

_____mL for a 450mL blood
_____ mL for a 500mL blood

A

100
110

Q

Chemicals in anticoagulant solution

Chelates Calcium

a. Citrate
b. Monobasic sodium phosphate
c. Dextrose
d. Adenine
e. Mannitol

A

a

Q

Chemicals in anticoagulant solution

Maintains pH during Storage

a. Citrate
b. Monobasic sodium phosphate
c. Dextrose
d. Adenine
e. Mannitol

A

b

Q

Chemicals in anticoagulant solution

Production of ATP

a. Citrate
b. Monobasic sodium phosphate
c. Dextrose
d. Adenine
e. Mannitol

A

d

Q

Chemicals in anticoagulant solution

Substrate for ATP

a. Citrate
b. Monobasic sodium phosphate
c. Dextrose
d. Adenine
e. Mannitol

A

c

Q

Chemicals in anticoagulant solution

Protect against storage-related hemolysis

a. Citrate
b. Monobasic sodium phosphate
c. Dextrose
d. Adenine
e. Mannitol

A

e

Q

Process by which ATP and 2,3 DPG levels are restored or enhance by metabolic alterations

A

Rejuvenation solution

Q

Process of reviving RBC

A

Rejuvenation solution

Q

What are the Rejuvenation Solutio?

A

PIGPA

Pyruvate
Inosine
Glucose
Phosphate
Adenine

Q

The only FDA approved rejuvenation solution

A

Rejuvesol

Q

RBC storage Lesions:

Percent of viable cells
Glucose
ATP
pH
2,3 -DPG

Decrease or Increase

A

Decrease

Q

RBC storage Lesions:

Plasma potassium
Plasma hemoglobin
Lactic acid

Decrease or Increase

A

Increase

Q

in RBC storage lesions

Oxgen Dissociation curve is Shift to the right or left?

A

Shift to the Left

Q

Pathogen Reduction technology includes

UV irradiation and Photo sensitizers
Psoralen Treatment

Decrease the the risk of transmissble blood disease

T or F

A

T

Q

Removal of WBCs from blood or blood components prior to transfusion

A

Leukoreduction

Q

Leukoreduction are given to patient with Anti-WBC

T or F

A

T

Q

Febrile nonhemolytic transfusion reaction

Transfusion Related acute lung injury

Both of this requires leukoreduce

T or F

A

T

Q

Residual WBC per each whole blood, RBC or apheresis Platelet

<5.0 x 10^6
<8.3 x 10^5
>85%

A

<5.0 x 10^6

Q

_____ of the original component must be recovered after leukoreduction

<5.0 x 10^6
<8.3 x 10^5
>85%

A

85%

Q

Residual WBC per each Platelets derived from whole blood

<5.0 x 10^6
<8.3 x 10^5
>85%

A

<8.3 x 10^5

Q

Leukoreuduction categories:

Shortly after collection

a. Prestorage
b. Post-storage

A

a

Q

Leukoreuduction categories:

Shortly after collection

a. Prestorage
b. Post-storage

A

a

Q

Leukoreuduction categories:

At the patient’s bedside

a. Prestorage
b. Post-storage

A

b

Q

Filters is made up of multiple layers of Polyester or cellulose acetate nonwoven fibers that trap leukocytes and platelets

T or F

A

T

Q

Pore size: 17um
Removes fibrin clot

First generation Filters
second generation Filters
Third generation filters

A

First

Q

Pore size: 20-40um
Removes micro aggregates

First generation Filters
second generation Filters
Third generation filters

A

Second

Q

Removes 99.9% WBC

First generation Filters
second generation Filters
Third generation filters

A

Third

Q

Pther methods to acheive RBC leukoreduction:

A

Centrifugation
Washing
Freezing
Thawing
Deglycerolizing