6.1 Apheresis Flashcards
Collection of a specific blood component while returning the remaining whole blood components back to the patient
Apheresis
In apheresis, the remaining whole blood that returns to the patient is based on Differences in?
Density
Advantages in Apheresis:
Small Volume of blood
Removal of unwanted substance
T or F
F
Large volume
Anticoagulant for apheresis
Citrate
Methods of centrifugation:
One puncture site for blood to be collected
a. Intermittent Flow Centrifugation
b. Continuous Flow Centrifugation
a
Methods of centrifugation:
Blood is processed in batches or cycles
a. Intermittent Flow Centrifugation
b. Continuous Flow Centrifugation
a
Methods of centrifugation:
2 Punture Cite (1 for blood collection, 1 for returning of blood components)
a. Intermittent Flow Centrifugation (IFC)
b. Continuous Flow Centrifugation (CFC)
b
Methods of centrifugation:
Blood withdrawal, processing, reinfusion are performed simultaneously in a on going manner
a. Intermittent Flow Centrifugation (IFC)
b. Continuous Flow Centrifugation (CFC)
b
Methods of centrifugation:
Which is one is faster?
a. Intermittent Flow Centrifugation (IFC)
b. Continuous Flow Centrifugation (CFC)
b
Type of apheresis
Plasma
Plasmapheresis
Type of apheresis
Platelet
Plateletpheresis (Single donor platelet concentration)
Type of apheresis
Leukocytes
Leukapheresis
Type of apheresis
RBC
Erythrocythapheresis
Type of apheresis
Hematopoietic progenitor cells
HPC apheresis
In Leukapheresis:
Sedimenting agent
a. Hydroxyethyl starch
b. Corticosteroids
c. Growth Factors
a
In Leukapheresis:
Increases Leukocytes harvest
a. Hydroxyethyl starch
b. Corticosteroids
c. Growth Factors
b and c
In Leukapheresis:
Separated WBC from other cell
a. Hydroxyethyl starch
b. Corticosteroids
c. Growth Factors
a
In Leukapheresis:
Prednisone or dexamethaone
a. Hydroxyethyl starch
b. Corticosteroids
c. Growth Factors
b
Process of collecting 2 units of red cell
Double RBC Pheresis
What do you call apheresis for platelets?
Single donor concentrate
What do you call platelet coming from Whole blood collection?
Random donor platelets
How many random donor platelets for Plateletpheresis
6-8
FDA Guidelines for 2RBC
Male:
_____lbs, minimum height _____
130, 5’1
FDA Guidelines for 2RBC
Female:
_____lbs, minimum height _____
150, 5’5
FDA Guidelines for 2RBC
Hematocrit?
40%
In plasmapheresis:
No more than one procedure in a 4 week period
a. Infrequent donor
b. Serial donor
a
In plasmapheresis:
Donate more frequently than 4 weeks
a. Infrequent donor
b. Serial donor
b
A Pathologenic substance exists in the blood that contributes to a disease process or its symptoms
Therapeutic cytapheresis
Indication categories for therapeutic Apheresis:
Apheresis is standard and acceptable, either as primary therapy or as a first line adjunt to other initial therapies
I
Indication categories for therapeutic Apheresis:
Apheresis has been demonstrated to lack efficacy or be harmful and should be discouraged in these disorders
IV
Indication categories for therapeutic Apheresis:
Apheresis is not clearly indicated based on insufficient evidence, conflicting results, or inability to document a favorable risk-to-benefit ratio
III
Indication categories for therapeutic Apheresis:
Apheresis is generally accepted in a supportive role or as second-line therapy, rather than first-line therapy
II
