9. Regeneration 3

Question 1

Name the 4 components of the repair process.

Answer 1

1. Angiogenesis
2. Migration and Proliferation of Fibroblasts
3. Deposition of ECM
4. Remodeling

Question 2

What is granulation tissue and when does it appear.

Answer 2

1. New blood vessels + fibroblasts

2. 3-5 days after tissue repair begins

Question 3

Distinguish vasculogenesis from angiogenesis.

Answer 3

V-formation of brand new blood vessels

A-extensions of new blood vessels from old ones

Question 4

Name 2 factors that influence vasodilation.

Answer 4

1. NO

2. VEGF

Question 5

Name the 2 MOST IMPORTANT factors in angiogenesis.

Answer 5

1. bFGF (basic fibroblast growth factor)

2. VEGF

Question 6

Name and describe the 3 phases of cutaneous wound healing.

Answer 6

1. Inflammation - platelet aggregation and adhesion
2. Proliferation - formation of granulation tissue
3. Maturation - deposition of ECM

Question 7

Simplest type of cutaneous wound repair, ex. surgical incision.

Answer 7

Primary Union or First Intension

Question 8

This often occurs during secondary union in order to aid in healing the wound.

Answer 8

Contraction of the wound

Question 9

2 major functions of a clot.

Answer 9

1. Stop bleeding

2. Serve as scaffolding for migrating immune and repair cells

Question 10

The hallmark of tissue repair.

Answer 10

Granulation Tissue

Question 11

First immune cells to arrive during injury and cells that replace them at 48hrs.

Answer 11

1. Neutrophils

2. Macrophages

Question 12

Migration and proliferation of fibroblasts is done by PDGF, EGF, TGF-β, FGF, and the cytokines IL-1 and TNF which are secreted by which cells?

Answer 12

Macrophages

Question 13

Most important fibrogenic agent.

Answer 13

TGF-Beta (tissue growth factor Beta)

Question 14

About what time does the granulation tissue form a pale scar after injury?

Answer 14

1 month after injury

Question 15

Name the 3 categories that lead to abnormal wound healing.

Answer 15

1. Deficient scar formation
2. Excessive scar formation
3. Formation of contractures

Question 16

List and describe the 2 types of deficient scar formation.

Answer 16

1. Wound dehiscence - rupture of a closed wound like after surgery
2. Ulceration

Question 17

Hypertrophic scar resulting from too much synthesis of repair components.

Answer 17

Keloid