Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology Exam II > 9: Host Defense > Flashcards

9: Host Defense Flashcards

1
Q

extracellular bacteria innate immunity

A

1 Phagocytosis

  1. alternative complement pathway
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

extracellular bacteria adaptive immunity

A

Humoral immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

extracellular bacteria evasion

A

polysaccharide capsules

genetic variation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

extracellular bacteria deleterious effects

A

septic shock
superantigens
disease-causing antibodies (cross-reactive antibodies and immune complexes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

intracellular bacteria innate immunity

A
  • some killed, but adaptive required for eradication

- NKC activated by macrophage-produced IL-12 produces INFgamma to activate macrophages (circle)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

intracellular bacteria adaptive immunity

A

DTH-like type IV reaction

- TH1 cells release IFNgamma to activate macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

intracellular bacteria evasion

A
  • mycobacterium: inhibits fusion of phagosomes and lysosomes

- listeria: disrupts phagosome and escapes into cytosol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

intracellular bacteria deleterious effects

A

granulomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

viruses innate immunity

A
  • IFN produced by infected cell protects the surrounding cells by upregulating class I MHC and activating NK cells
  • NK cells lyse early in infection (1st line of defense against virus infected cells)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

viruses adaptive immunity

A
  • humoral if antibodies are present (before inside cell) because prevents virus binding to target cell
  • CTLs are main immune defense against establish virus infections
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

viruses evasion

A
  • antigenic variability (via error-prone reverse transcriptase)
  • antigenic alteration ( via reassortants)
  • prevention of class I MHC expression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

viruses deleterious effects

A
  • CTL mediated pathologic lesions (Hep B and liver)

- molecular mimicry (cross-reaction with host tissue)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

fungal innate immunity

A

Neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

fungal adaptive immunity

A

TH1 mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

parasite innate immunity

A
  • macrophages try to phagocytize protozoa

- helminths activate alternative complement but they are resistant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

parasite adaptive immunity

A
  • worms: IgE and eosinophils during ADCC (TH2 immunity)
  • Plasmodium (cause malaria): TH1 mediated CTLs
  • Eggs in liver: CD4 T cells recruit macros to wall off eggs in granulomas
  • Protozoa within macrophages: CD4 T cells produce IFNgamma to activate macrophages
17
Q

parasite deleterious effects

A
  • immune complexes (chronic parasite infestations)
  • liver fibrosis and cirrhosis (eggs)
  • lymphedema/elephantitis (filaria worms)

Immunology Exam II (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions