9. CARDIAC and RENAL: Angoitensin-renin system, BP, and Big 3

Question 1

Start of the angiotensin-renin system

Answer 1

Juxtaglomerular apparatus secretes renin

Question 2

After renin is secreted, then what?

Answer 2

renin converts angiotensinogen into Angiotensin I

Question 3

After Angiotensin I is made, then what?

Answer 3

Angiotensin I is converted into ANgiotensin II

Question 4

What is ANgiotensin II

Answer 4

the ultimate raiser of blood pressure

Question 5

What are Angiotensin’s 3 primary actions?

Answer 5

increase sympathetic activity, increase ADH secretion and increase aldosterone secretion

Question 6

What part(s) of the big 3 are affected by increased sympathetic activity?

Answer 6

Cardiac output 2 ways (HR up, stroke volume up), Resistance (by increasing vasoconstriction

Question 7

What part(s) of the big 3 are affected by ADH secretion?

Answer 7

Blood volume (causes H2O reabsorption)

Question 8

What part(s) of the big 3 are affected by aldosterone secretion?

Answer 8

Blood volume (causes sodium reabsorption)

Question 9

What if the local adjustment of glomerular hydrostatic pressure fails to solve a problem of a glomerular filtration rate that is too HIGH?

Answer 9

BP is then too high and the heart will secrete natriuretic peptide, that do the opposite of Angiotensin II