8a. Bleeding In Early Pregnancy Flashcards
What percentage of pregnancies experience early pregnancy bleeds
25%-30%
What percentage of early bleed pregnancies go on to abort spontaneously
50%
What are four Non pregnancy related causes of Early Pregnancy bleed
Cervicitis
Vaginitis
Vaginal lacerations
Cervical carcinoma
What are four pregnancy related causes of early pregnancy bleeds
Physiological bleeding
Spontaneous miscarriage
Ectopic Pregnancy
Molar Pregnancy
What are two causes of physiological bleeding of early pregnancy
Bleeding secondary to implantation
Relative deficiency in hormones (progesterone)
Physiological bleeding of early pregnancy is likely due to disruption of which vessels
Decidual vessels at the maternal-fetal interface
What are four Clinical Features of physiological bleeding of early pregnancy
Bleeding is usually minimal
Bleeding usually occurs within the first eight weeks of pregnancy
No associated pelvic pain
No cervical dilatation
Physiological bleeding of early pregnancy usually occurs within which weeks of pregnancy
First 8 weeks
List three steps in management of Physiological Bleeding of early pregnancy
Avoid Strenuous activity
Folic acid 5mg daily
Progesterone
What is the prognosis for Physiological Bleeding of early pregnancy
Usually good 90%-96%
What are the fetal risks for Physiological Bleeding of early pregnancy
Slight increased risk for low birthweight,
Premature labour
Neonatal mortality
Define Spontaneous Miscarriage
It is a natural termination of a pregnancy before the fetus is capable of extra uterine life (<24 weeks)
List five clinical stages of miscarriage
Threatened miscarriage Inevitable miscarriage Incomplete miscarriage Complete miscarriage Delayed
Define Threatened Miscarriage (TM)
A pregnancy presenting with bleeding before 24weeks of gestation
(Cervical orifice closed)
A pregnancy presenting with bleeding before 24weeks of gestation
(Cervical orifice closed)
Threatened miscarriage TM
Define an Inevitable Miscarriage IM
It is considered inevitable when there is bleeding and the cervical os is open
What type of Miscarriage presents with a bleed and the cervical os is open
Inevitable miscarriage IM
Define an Incomplete Miscarriage
This is the passage of some but not all of the products of conception POC
from the uterine cavity through the cervical canal before 24weeks of gestation
What type of Miscarriage: This is the passage of some but not all of the products of conception POC
from the uterine cavity through the cervical canal before 24weeks of gestation
Incomplete Miscarriage
Define a complete miscarriage
This is characterized by the total expulsion of Products of conception and resolution of symptoms
What type of Miscarriage: This is characterized by the total expulsion of Products of conception and resolution of symptoms
Complete miscarriage
Describe the Cervical os and Uterus in Complete Miscarriage
Cervical os is close
Empty uterus
Define a delayed miscarriage DM/ missed abortion
Retention of a dead embryo
Retention of a dead embryo
Delayed Miscarriage/ MissedAbortion
Define a blighted ovum
Failure or absence of an embryo at a very early stage of pregnancy- a sac/ placenta grows with no fetus
Failure or absence of an embryo at a very early stage of pregnancy
Blighted ovum
List six causes of Spontaneous Miscarriage
Chromosomal abnormalities Uterine or cervical factors Endocrine causes Immunological Disorders Teratogens and Infections Unknown
Give an example of a teratogen that can lead to Spontaneous Miscarriage
Mercury
Give an example of an infection that can lead to Spontaneous Miscarriage
Rubella
What percentage of spontaneous miscarriages are caused by chromosomal abnormalities
50%
What percentage of spontaneous miscarriages are caused by uterine or Cervical factors
5 to 10%
What percentage of spontaneous miscarriages are caused by Endocrine causes
20%
What percentage of spontaneous miscarriages have unknown origin
15%
List three types of chromosome abnormalities that can lead to spontaneous miscarriage
Autosomal trisomy
Monosomy
Triploids
Which chromosomal abnormality type most often causes spontaneous miscarriage
Autosomal trisomy
Trisomy 21, 18, 16
What causes Monosomy (45XO; turner)
Loss of paternal sex chromosome
Monosomy occurs in what percentage of Spontaneous Miscarriage
7%
Triploids occur in what percentage of Spontaneous Miscarriage
8-9%
What causes Triploids
It is the consequence of either dispermy or failure of extrusion of the second polar body
List three uterine abnormalities that can lead to Spontaneous Miscarriage
Septate uterus
Fibroids (submucous)
Polyp >2cm diameter
What are four Endocrine cause of Spontaneous Miscarriage
Poorly treated diabetes (type1/type2)
Hypothyroidism and Hyperthyroidism
Cushing Syndrome
PCOS (Polycystic Ovarian Syndrome)
What are some clinical features of Spontaneous Miscarriage
Loss of pregnancy symptoms
Vaginal bleeding
Pelvic pain
Passage of products of conception POC
Which tests are used to help predict or diagnose Spontaneous Miscarriage
Ultrasonography
With or without beta-hCG test
Expectant management of Spontaneous Miscarriage is indicated in patients when the ultrasound test shows what results
Ultrasound detects little tissue in the uterus with low or falling hCG
What is the medical management of Spontaneous Miscarriage
Misoprostal
Or//
Mifepristone (progesterone antagonist) and Misoprostal
Outline the Surgical management of Spontaneous Miscarriage
Evacuation of retained products of conception ERPC
(Currettage/suction)
List three steps in Post abortion care and counselling
Women advised to maintain Pelvic Rest ( nothing per vagina) until two weeks after evacuation
Grief counseling
Women who are Rh(D) -negative and unsensitized
Should receive Rh(D) -immune globulin following surgical events
Why should
Women who are Rh(D) -negative and unsensitized
Should receive Rh(D) -immune globulin following surgical events
RHO (D) immune globulin is used to prevent antibodies from forming after a person or when a mother has RH negative blood and the baby is Rh positive blood
What is the risk of miscarriage in future pregnancy after one miscarriage ?
20%
What is the risk of miscarriage in future pregnancy after two miscarriages
30%
What is the risk of miscarriage in future pregnancy after three or more miscarriages
40-50%