8.1.2014

Question 1

side effects of IV acyclovir

Answer 1

nephrotoxicity

neurotoxicity

Question 2

acyclovir congener with long t1/2

Answer 2

valacyclovir

Question 3

dose limiting adverse effect of ganciclovir

Answer 3

myelosuppression

Question 4

dose limiting toxicity of cidofovir

Answer 4

nephrotoxicity

Question 5

cidofovir is active against

Answer 5

HSV
CMV
adeno virus
papilloma virus

Question 6

advantage of foscarnet over other related anti virals

Answer 6

Does not need activation by host cell or viral kinases

Question 7

side effect of foscarnet

Answer 7

nephrotoxicity
hypocalcemia
hypomagnesemia

Question 8

anti sense oligonucleotide active against CMV

Answer 8

fomivirsen

Question 9

amantidine and rimantidine are active only against

Answer 9

Influenza A

Question 10

neuraminidase inhibitor that can be given IV

Answer 10

peramivir

Question 11

route of admn of zanamavir

Answer 11

inhalational

Question 12

drug of choice for chronic HBV

Answer 12

entecavir

Question 13

adverse effect of ribavirin

Answer 13

dose dependant hemolytic anemia

Question 14

new drugs for hepatitis C

Answer 14

sofosbuvir

simprevir

Question 15

beta tubulin polymerisation inhibitors

Answer 15

albendazole
mebendazole
thiabendazole
triclabendazole

Question 16

anti helminths causing spastic paralysis

Answer 16

pyrantel

levamisole

Question 17

anti helminths causing flaccid paralysis

Answer 17

piperazine

ivermectin

Question 18

mech of action of praziquantel

Answer 18

influx of calcium

Question 19

drug of choice for all nematode infections

Answer 19

albendazole

Question 20

DOC for enterobius

Answer 20

mebendazole

Question 21

Ivermectin is drug of choice for

Answer 21

onchocerca

strongyloides

Question 22

DOC for dracunculiasis

Answer 22

metronidazole

Question 23

DOC for all trematode and cestode infections

Answer 23

praziquantal

Question 24

DOC for fasciola hepatica

Answer 24

triclabendazole

Question 25

DOC for hydatid disease

Answer 25

albendazole

Question 26

endogenous antiepileptic substance

Answer 26

adenosine

Question 27

antiepileptics acting by use dependant Na+ blockade

Answer 27

``` phenytoin carbamazepine SVP lamotrigene topiramate lacosamide ```

Question 28

MOA of ganaxolone

Answer 28

GABAnergic

Question 29

felbamate inhibits

Answer 29

NMDA receptors

Question 30

topiramate inhibits

Answer 30

kainate receptors

Question 31

characteristic adverse effect of trimethadone

Answer 31

hemarlopia(photophobia+glare effect)

Question 32

vigabatrin is DOC for

Answer 32

infantile spasms associated with tuberous sclerosis

Question 33

DOC for infantile spasms

Answer 33

ACTH

Question 34

adverse effects of vigabatrin

Answer 34

retinal atrophy

Question 35

anti epileptic indicated in depressive phase of bipolar disorder

Answer 35

lamotrigene

Question 36

adverse effect of lamotrigene

Answer 36

SJS/TEN

Question 37

DOC for diabetic and post herpetic neuralgia

Answer 37

GABApentin

Question 38

anti epileptics that can cause renal stones

Answer 38

zonisamide | topiramate

Question 39

antiepileptic that can cause weight loss

Answer 39

topiramate

Question 40

adverse effect of felbamate

Answer 40

hepatotoxicity | aplastic anemia

Question 41

anti epileptic that is an AMPA receptor inhibitor

Answer 41

perampanel

Question 42

newly approved drug for lennox gestaut

Answer 42

rufinamide

Question 43

drugs for absence seizures

Answer 43

``` SVP ethosuximide lamotrigene trimethadone ganoxolone ```

Question 44

CCB causing hyperprolactinemia

Answer 44

verapamil

Question 45

sulfasalazine is a combination of

Answer 45

5-ASA and sulfapyridine

Question 46

adverse effects of sulfapyridine

Answer 46

nausea,vomiting bone marrow suppression oligospermia