27.12.13

Question 1

Drug that should not be combined with zidovudine

Answer 1

ganciclovir

Question 2

Contraindication to zidovudine

Answer 2

Hb< 8 g%

Question 3

Effect of rifampicin on AZT

Answer 3

increases the clearance of AZT

Question 4

Chronic admn of AZT is associated with

Answer 4

Lipodystrophy
Lipoatrophy
Nail hyperpigmentation

Question 5

Max chances of _________ and _________ are with didanosine

Answer 5

pancreatitis

diarrhoea

Question 6

hematological side effect of didanosine

Answer 6

neutropenia

Question 7

adverse effects of didanosine

Answer 7

hyperuricemia
optic neuritis
painful sensory peripheral neuropathy
fulminant hepatic failure

Question 8

most common cause of lipodystrophy amongst ART

Answer 8

stavudine

Question 9

stavudine has the maximum chance of causing

Answer 9

lactic acidosis

Question 10

similar adverse effects of stavudine and didanosine

Answer 10

pancreatitis

peripheral neuropathy

Question 11

Best tolerated NRTI

Answer 11

lamivudine

emtricitabine

Question 12

advantage of emtricitabine over lamivudine

Answer 12

once a day dosing

Question 13

Least effective NRTI

Answer 13

zalcitabine

Question 14

side effect of zalcitabine

Answer 14

oral ulceration

stomatitis

Question 15

Testing of which allele should be done before starting abacavir

Answer 15

HLA B*5701

Question 16

abacavir increases the risk of

Answer 16

MI

Question 17

all NRTI are excreted by kidney except

Answer 17

ABC

Question 18

abacavir is metabolised by

Answer 18

alcohol dehydrogenase

Question 19

Interaction of NRTI with food

Answer 19

food decreases oral bioavailability

Question 20

adverse effect of tenofovir

Answer 20

fanconi like syndrome with hypophosphatemia

Question 21

oral bioavailability of tenofovir is ____________ with meals

Answer 21

decreased

Question 22

side effect of tenofovir

Answer 22

flatulence

Question 23

ARTs active against hepatitis B

Answer 23

lamivudine
emtricitabine
tenofovir

Question 24

which drugs are selective for HIV 1

Answer 24

NNRTI(no effect against HIV 2)

Question 25

adverse effect of NNRTI

Answer 25

skin rash

Question 26

NNRTI avoided in pregnancy

Answer 26

efavirenz | delaviridine

Question 27

side effects of efavirenz

Answer 27

delusions mania vivid dreams

Question 28

2nd gen NNRTI

Answer 28

etravirine | rilpivirine

Question 29

ART that donot cause lipodystrophy

Answer 29

NNRTI

Question 30

effect of NNRTI on cyp450

Answer 30

nevirapine and efavirenz are inducers | delaviridine is an inhibitor

Question 31

adverse effects of indinavir

Answer 31

crystalluria | asymptomatic hyperbilirubinemia

Question 32

PI for which ritonavir boosting is not recommended

Answer 32

nelfinavir

Question 33

concentration of amprenavir and fosamprenavir decrease when co admn with

Answer 33

ethynyl estradiol

Question 34

PI effective against HIV resistant to other PI

Answer 34

tipranavir

Question 35

adverse effects of tipranavir

Answer 35

hepatotoxicty | ICH

Question 36

PI that does not cause lipodystrophy

Answer 36

atazanavir

Question 37

PIs causing asymptomatic hyperbilirubinemia

Answer 37

indinavir | atazanavir

Question 38

cardiac effect of atazanavir

Answer 38

PR prolongation

Question 39

atazanavir should not be given along with

Answer 39

proton pump inhibitors

Question 40

Atazanavir must be boosted with ritonavir when coadministered with

Answer 40

tenofovir and efavirenz

Question 41

ARTs that cause SJS

Answer 41

nevirapine | amprenavir

Question 42

drug that can be used to treat HIV associated lipodystrophy

Answer 42

tesamorelin

Question 43

mech of action of enfuviritide

Answer 43

binds to gp41 subunit of HIV

Question 44

drug used to boost the effect of elvitegravir

Answer 44

cobicistat