16.12.13

Question 1

Major effects of fibrates

Answer 1

reduce TGs and increase HDL

Question 2

Mech of action of fibrates

Answer 2

activate LPL by activating PPAR alpha

reduce apoCIII synthesis

Question 3

Available fibrates

Answer 3

clofibrate(not available)
gemfibrosil
fenofibrate
bezafibrate

Question 4

Fibrate with longest half life

Answer 4

fenofibrate

Question 5

Fibrate with maximum LDL lowering action

Answer 5

fenofibrate

Question 6

Additional advantage of fenofibrate

Answer 6

uricosuric

Question 7

effect of fibrates on plasma fibrinogen levels

Answer 7

reduces

Question 8

fibrates are drugs of choice for

Answer 8

Hypertriglyceridemia(esp after use of protease inhibitors)

Question 9

Fibrate without increased risk of myopathy

Answer 9

bezafibrate

fenofibrate+rosuvastatin combination

Question 10

adverse effects of fibrates

Answer 10

GI distress
elevated transaminases
hypokalemia
cholesterol gall stones
Leukopenia
decreased Hct

Question 11

absorption of gemfibrosil is increased with

Answer 11

food

Question 12

Interaction of fibrates

Answer 12

potentiate coumadin anticoagulants and OHA

Question 13

At what level of TGs should fibrates be started

Answer 13

> 500mg/dl

Question 14

Spectrum of activity of daptomycin

Answer 14

similar to vancomycin

also active against Vanco resistant enterococci and S.aureus

Question 15

adverse effect of daptomycin

Answer 15

myopathy

Question 16

datomycin is not useful for treatment of

Answer 16

pneumonia

surfactant inactivates it

Question 17

daptomycin is eliminated

Answer 17

renally

Question 18

mech action of daptomycin

Answer 18

Ca+ mediated pore formation in cellwall resulting in K+ efflux

Question 19

Drug of choice for hypertensive emergencies

Answer 19

SNP

Question 20

Mech of action of SNP

Answer 20

release NO

stimulate guanylyl cyclase

Question 21

DOC for hypertensive emergencies in pregnancy

Answer 21

hydralazine

Question 22

Adverse effects of SNP

Answer 22

cyanide toxicity in renal failure

hypothyroidism due to accumulation of thiocyanates

Question 23

Dose range of SNP

Answer 23

0.5 ug/kg/min-10ug/kg/min

Question 24

SNP is sensitive to

Answer 24

light

Question 25

Treatment of cyanide poisoning due to SNP

Answer 25

sodium thiosulphate | hydroxy cobalamin

Question 26

Manifestations of thiocyanate toxicity

Answer 26

``` weakness disorientation psychosis muscle spasms convulsions ```

Question 27

Bosentan

Answer 27

non selective endothelin receptor blocker

Question 28

selective ET-A receptor blocker

Answer 28

sitaxsentan | ambrisentan

Question 29

Endothelin converting enzyme inhibitor

Answer 29

phosphoramidan

Question 30

Adverse effects of endothelin antagonists

Answer 30

hepatotoxicity pregnancy peripheral edema

Question 31

Bosentan drug interactions

Answer 31

CI in pts taking glyburide,glipizide and cyclosporine

Question 32

Adverse effects of sitagliptin

Answer 32

nasopharyngitis URI headaches pancreatitis

Question 33

DPPIV inhibitors have a preferential effect on

Answer 33

postprandial glucose levels

Question 34

Amount of HbA1C reduction produced by DPPIV inhibitors

Answer 34

0.5-0.8

Question 35

dose of DPP IV inhibitors must be reduced with

Answer 35

renal failure

Question 36

Adverse effects of saxagliptin

Answer 36

facial edema | urticaria

Question 37

Carbepenems

Answer 37

imipenem doripenem meropenem ertapenem

Question 38

Most effective carbepenem for pseudomonas infection

Answer 38

meropenem combined with aminoglycosides

Question 39

Carbepenems are drugs of choice for

Answer 39

enterobacter klebsiella acinetobacter ESBL

Question 40

Cilastatin is an inhibitor of

Answer 40

renal dehydropeptidase I

Question 41

Adverse effect of imipenem cilastatin

Answer 41

seizures | GI effects

Question 42

carbepenems are sensitive to which beta lactamase

Answer 42

metallo-beta lactamase

Question 43

organisms resistant to carbapenems

Answer 43

``` E.fecium MRSA Cl.Difficle Burkholdria cepecia stenotrophomonas maltophilla ```

Question 44

Carbapenem with longest half life

Answer 44

ertapenem